南方医科大学学报

南方医科大学学报 ›› 2006, Vol. 26 ›› Issue (12): 1794-1796.

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左旋炔诺酮宫內缓释系统治疗子宫腺肌病的临床研究

何淑明； 张阳德；   

  1. 中南大学卫生部肝胆肠研究中心小榄基地； 中南大学卫生部肝胆肠研究中心小榄基地 广东中山528415； 广东中山528415；
  • 出版日期:2006-12-20 发布日期:2006-12-20
  • 基金资助:
    广东省医学科学技术研究基金项目(A2003884)~~

Clinical study of levonorgestrel-releasing intrauterine system for adenomyosis

HE Shu-ming,ZHANG Yang-de Xiaolan Station of Zhongnan University,National Hepatobiliary and Enteric Surgery Research Center,Ministry of Health,Zhongshan 528415,China   

  1. 中南大学卫生部肝胆肠研究中心小榄基地； 中南大学卫生部肝胆肠研究中心小榄基地 广东中山528415； 广东中山528415；
  • Online:2006-12-20 Published:2006-12-20

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摘要： 目的探讨左旋-18甲基炔诺酮宫內缓释系统(LNG－IUS)治疗子宫腺肌病的临床疗效及其副反应。方法对70例子宫腺肌病的患者,宫内放置LNG-IUS治疗,观察月经情况、痛经程度、子宫体积变化及对人体肝功能、血脂等的影响。结果放置LNG-IUS后,月经量显著减少,第1个月为原来的(35±12)%(P<0.01),12个月后为(7±4)%(P<0.01);治疗3个月后子宫体积平均缩小18.6%(P<0.05);痛经显著缓解或完全消失;贫血迅速改善,对人体肝功能、血脂无明显不良副作用。结论LNG-IUS治疗子宫腺肌病疗效显著,安全性好。 更多还原

Abstract: Objective To investigate the clinical efficacy of levonorgestrel-releasing intrauterine system(LNG-IUS)in the treatment of adenomyosis.Methods Seventy patients with adenomyosis diagnosed according to clinical symptoms,magnetic resonance imaging(MRI)findings,laparoscopy and/or color-Doppler ultrasound imaging were treated with LNG-IUS,and the menstrual blood volume,dysmenorrhea,uterine volume,hepatic function and serum lipids were observed and evaluated.Results In the first month of treatment,the menstrual blood size was reduced significantly to(35±12)% of that before treatment(P<0.01),and further to(7±4)% in the twelfth month(P<0.01).The average uterine volume was decreased by 18.6%(P<0.05)after the treatment,and dysmenorrhea was obviously relieved or completely disappeared alleviated.The condition of anemia was also improved rapidly,and no obvious side-effects on hepatic function and serum lipids were observed.Conclusion LNG-IUS is an effective and safe therapy for adenomyosis.

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