南方医科大学学报

南方医科大学学报 ›› 2006, Vol. 26 ›› Issue (11): 1612-1615.

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食管鳞癌RhoC和OPN蛋白的表达及其对患者预后的影响

张惠忠； 刘金耿； 魏益平； 吴澄； 曹永科； 王梅；   

  1. 中山大学附属第二医院心胸外科； 中山大学附属第二医院心胸外科 广东广州510120； 广东广州510120；
  • 出版日期:2006-11-20 发布日期:2006-11-20
  • 基金资助:
    广东省重点科技攻关项目(2003B30104)~~

Expressions of RhoC and osteopontin in esophageal squamous carcinoma and association with the patients’ prognosis

ZHANG Hui-zhong,LIU Jin-geng,WEI Yi-ping,WU Cheng,CAO Yong-ke,WANG Mei Department of Cardiothoracic Surgery,Second Affiliated Hospital,Sun Yat-sen University,Guangzhou 510120,China   

  1. 中山大学附属第二医院心胸外科； 中山大学附属第二医院心胸外科 广东广州510120； 广东广州510120；
  • Online:2006-11-20 Published:2006-11-20

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摘要： 目的研究食管鳞癌组织中RhoC和OPN蛋白的表达及其与食管鳞癌生物学行为之间的关系。方法采用免疫组织化学方法(二步法)检测80例食管鳞癌组织中RhoC和OPN蛋白的表达情况,探讨它们与食管鳞癌肿瘤大小、组织分化程度、TNM分期、淋巴结转移和预后的关系。结果(1)RhoC蛋白在食管鳞癌组织中的阳性表达率为66.25%,其表达与淋巴结转移有关(rs=-2.115,P<0.05),而与肿瘤大小、组织分化程度和TNM分期无关(P>0.05);RhoC蛋白阳性表达组患者的术后生存时间较阴性表达组短,(P<0.001);(2)OPN蛋白在食管鳞癌组织中的阳性表达率为100%,OPN蛋白的表达水平与组织分化程度(χ2=10.766,P<0.05)及淋巴结转移有关(rs=-2.289,P<0.05),而与肿瘤大小和TNM分期无关(P>0.05);OPN蛋白的表达水平越高,患者术后生存时间越短(P<0.05);(3)RhoC蛋白和OPN蛋白在食管鳞癌组织中的表达之间存在正相关性(rs=0.408,P<0.001)。结论食管鳞癌组织RhoC和OPN蛋白的表达与淋巴结转移情况及患者的预后有密切关系,RhoC蛋白和OPN蛋白可作为食管鳞癌预后评价的参考指标。

Abstract: Objective To investigate the expressions of RhoC and osteopontin(OPN) protein in esophageal squamous carcinoma(ESC) and their association with the biological behavior of ESC.Methods The expressions of RhoC and OPN protein were detected in 80 ESC cases by immunohistochemistry.Results The positive expression rate of RhoC was 66.25% in these ESC cases.The rate was significantly higher in cases with lymph node metastasis than in those without(rs=-2.115,P<0.05),but RhoC expression was not associated with the tumor diameter,differentiation or TNM grade(P>0.05).The RhoC-positive patients had significantly shorter survival time than the negative patients(P<0.001).All the 80 ESC patients were positive for OPN expression,and OPN expression levels were correlated with the differentiation(χ2=10.766,P<0.05) and lymph node metastasis of the tumor(rs=-2.289,P<0.05),but not with the tumor diameter or TNM grade(P>0.05).Higher expression level of OPN was closely related to shorter survival time of the patients(P<0.05).A positive correlation was found between RhoC protein and OPN expressions(rs = 0.408,P<0.001) in these cases.Conclusion The expressions of RhoC and OPN protein are closely related to lymph node metastasis of ESC and the patients survival time,and therefore may serve the purpose of prognostic evaluation of ESC. 

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