南方医科大学学报

南方医科大学学报 ›› 2006, Vol. 26 ›› Issue (10): 1481-1483.

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心脏原发性弥漫性大B细胞淋巴瘤临床病理学观察

吴正蓉； 翁德胜； 丁彦青； 韩慧霞； 朱梅刚；   

  1. 南方医科大学南方医院病理科； 南方医科大学南方医院病理科 广东广州510515； 广东广州510515；
  • 出版日期:2006-10-20 发布日期:2006-10-20

Primary diffuse large B-cell lymphoma of the heart: a clinicopathological study

WU Zheng-rong, WENG De-sheng, DING Yan-qing, HAN Hui-xia, ZHU Mei-gang Department of Pathology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China   

  1. 南方医科大学南方医院病理科； 南方医科大学南方医院病理科 广东广州510515； 广东广州510515；
  • Online:2006-10-20 Published:2006-10-20

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摘要： 目的探讨心脏原发性弥漫性大B细胞淋巴瘤的临床病理学特征。方法对1例心脏原发性弥漫性大B细胞淋巴瘤进行常规病理及免疫组化观察并复习相关文献。结果肿物位于右心房并向上下腔静脉延伸、部分与左心房壁相连,镜下为弥漫性增生的异型淋巴细胞,瘤细胞胞体大,胞浆丰富,间有瘤巨细胞。细胞核呈泡状,核膜厚,可见清晰的核仁。免疫组化CD20(++)、CD79a(+)。结论原发性心脏恶性淋巴瘤罕见,病因学尚不清楚,临床表现无特异性,绝大多数为B细胞系淋巴瘤,预后较差。

Abstract: Objective To define the clinicopathological features of primary cardiac large B-cell lymphoma. Method A case of primary cardiac large B-cell lymphoma was studied with conventional histopathological and immunohistochemical staining in combination with literature review. Results The lesion appeared to originate in the right atrium and involved the venae cavae and the left atrium. Microscopic examination showed diffuse proliferation of large atypical lymphocytes with abundant cytoplasm, vestiealer nuelei, thick nuclear membrane and conspicuous nucleoli. Giant tumor cells scattered in the lesion. The neoplastic cells were positive for CD20 and CD79a. Conclusion Primary cardiac lymphoma is extremely rare, and its pathogenesis remains unclear. With non-specific clinical manifestations, the majority of primary cardiac lymphomas are of B-cell lineage and a bad prognosis.. 

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