南方医科大学学报

南方医科大学学报 ›› 2006, Vol. 26 ›› Issue (10): 1476-.

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兔眶距增宽手术模型的建立与手术效果观察

袁强； 柳大烈； 袁继龙； 单磊；   

  1. 南方医科大学珠江医院整形外科； 南方医科大学珠江医院整形外科 广东广州510282； 广东广州510282；
  • 出版日期:2006-10-20 发布日期:2006-10-20

Establishment of rabbit orbital hypertelorism model and evaluation of effects of surgical correction

YUAN Qiang, LIU Da-lie, YUAN Ji-long, SHAN Lei Department of Plastic and Reconstructive Surgery, Zhujiang Hospital, Southern Medical University, Guangzhou 510282, China   

  1. 南方医科大学珠江医院整形外科； 南方医科大学珠江医院整形外科 广东广州510282； 广东广州510282；
  • Online:2006-10-20 Published:2006-10-20

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摘要： 目的建立兔眶距增宽修复重建手术的动物模型,研究了解眶距增宽矫正后眶周骨骼愈合及内眶距变化的规律。方法4-6月龄新西兰兔16只,行颅内外联合径路眶周截骨眶内移。全部16只兔在眶内移术后即刻和术后12周分别进行内眶距测量,X线摄片和组织学检查。结果术后即刻内眶距平均0.74cm,术后12周平均内眶距为0.96cm,有显著性差异(P<0.01)。X线和组织学检查见骨愈合处明显新骨生成,眶距增宽复发明显。结论使用颅内外联合径路眶周截骨眶内移技术可成功缩窄兔内眶距,是一种较理想的动物模型。 

Abstract: Objective To establish a rabbit model of orbital hypertelorism for plastic and reconstructive surgery and evaluate the surgical effects. Methods Orbital osteotomies and medial translocation was performed in 16 New Zealand rabbits (4 to 6 months old) by combined intracranial-extracranial approach. The interorbital distance (IOD) and bone healing between the orbits were evaluated with gross measurement. X-ray and histological examinations were performed immediately and 12 weeks after the operation. Results The average IOD of the rabbits was 0.74 cm after completion of the operation, but increased to 0.96 cm 12 weeks after the operation, showing significant relapse of orbital hypertelorism (P<0.01). Conclusion The IOD can be decreased successfully in this rabbit model. 

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