南方医科大学学报

南方医科大学学报 ›› 2006, Vol. 26 ›› Issue (10): 1446-1448.

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六味地黄丸对自发性2型糖尿病大鼠内脏脂肪分布的影响

薛耀明； 罗仁； 朱波； 张燕； 潘永华； 李晨钟；   

  1. 南方医科大学南方医院内分泌科； 南方医科大学南方医院内分泌科 广东广州510515； 广东广州510515；
  • 出版日期:2006-10-20 发布日期:2006-10-20
  • 基金资助:
    国家自然科学基金(30371839);广东省重点科技攻关项目(社会发展公关2003C34424);广东省科技计划(2004B30701011)~~

Liuweidihuang pills reduces visceral fat deposition in Otsuka Long-Evans Tokushima Fatty rats

XUE Yao-ming, LUO Ren, ZHU Bo, ZHANG Yan, PAN Yong-hua, LI Chen-zhong Department of Endocrinology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China   

  1. 南方医科大学南方医院内分泌科； 南方医科大学南方医院内分泌科 广东广州510515； 广东广州510515；
  • Online:2006-10-20 Published:2006-10-20

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摘要： 目的研究六味地黄丸对自发性2型糖尿病大鼠内脏脂肪堆积的影响。方法自发性2型糖尿病大鼠OLETF鼠40只,随机分为预防组和对照组,同系健康对照LETO鼠10只作为正常对照组。预防组于8周龄起以六味地黄丸2.4mg/kg每天1次灌胃给药,其余两组以等量清水灌胃。监测体质量,定期口服糖耐量试验检测血糖,分批宰杀分离并称量腹部脂肪。结果随病程进展,OLETF鼠内脏脂肪/体质量逐渐高于LETO组(P<0.05),在40周龄六味地黄丸预防组内脏脂肪/体质量显著低于对照组(P<0.01)。结论六味地黄丸能有效减少OLETF鼠内脏脂肪的堆积。 

Abstract: Objective To investigate the effects of Liuweidihuang pills (LP) on visceral fat deposition in Otsuka Long-Evans Tokushima Fatty (OLETF) rats. Methods Forty male OLETF rats were randomly divided into LP group and control group (n=20 per group), and 10 male Long-evans Tokushima Otsuka (LETO) rats were used as normal controls. The rats in LP group were given LP(2.4 mg/kg) daily by intragastric administration since the age of 8 weeks, and those in the other two groups were given water of the same volume by intragastric administration. Blood glucose of all the rats was determined by oral glucose tolerance test (OGTT) and visceral fat deposition examined after the rats were sacrificed. Results OLETF rats had obviously greater amount of visceral fat than LETO rats (P<0.05) and administration of LP ameliorated the increment of visceral fat deposition in this type 2 diabetic model, producing significant effect at the age of 40 weeks (P<0.01). Conclusion LP may effectively decrease visceral fat deposition in OLETF rats. 

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