南方医科大学学报

南方医科大学学报 ›› 2006, Vol. 26 ›› Issue (10): 1434-.

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精氨酸对糖尿病的作用观察

吕伟明； 雷尚通； 张强； 张赟建； 王深明； 石汉平；   

  1. 中山大学附属第一医院普通外科； 南方医科大学南方医院普通外科； 第二军医大学长征医院急救科； 中山大学附属第一医院普通外科 广东广州510080； 广东广州510515； 上海200003； 广东广州510080；
  • 出版日期:2006-10-20 发布日期:2006-10-20
  • 基金资助:
    美国NIH资助课题(GM54566)~~

Effect of L-arginine on diabetic rats

Lü Wei-ming1, LEI Shang-tong2, ZHANG Qiang3, ZHANG Yun-jian1, WANG Shen-ming1, SHI Han-ping1 1Department of General Surgery, First Affiliated Hospital of Sun Yat-sen University, Guangzhou 510080, China; 2Department of General Surgery, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China; 3Department of Emergency, Changzheng Hospital, Second Military Medical University, Shanghai 200003, China   

  1. 中山大学附属第一医院普通外科； 南方医科大学南方医院普通外科； 第二军医大学长征医院急救科； 中山大学附属第一医院普通外科 广东广州510080； 广东广州510515； 上海200003； 广东广州510080；
  • Online:2006-10-20 Published:2006-10-20

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摘要： 目的观察精氨酸对糖尿病的治疗作用。方法成年雄性Lewis大鼠,随机分为糖尿病组及正常对照组,前者以链脲佐菌素复制糖尿病模型,后者注射等量溶剂;7d后上述两组大鼠再随机分为精氨酸治疗组及盐水治疗组,每组10只大鼠;精氨酸治疗组每天腹腔注射L-精氨酸1g/kg,盐水治疗组每天注射等量生理盐水;10d后动物安乐死。观察动物血浆蛋白、精氨酸及葡萄糖浓度,动物体质量、摄食量及饮水量。结果与正常大鼠比较,糖尿病大鼠血浆蛋白及精氨酸减少、体质量下降、血糖升高、摄食量及饮水量增加;与盐水组比较,糖尿病大鼠经精氨酸治疗后体质量及血糖无显著变化,摄食及饮水量明显减少,血浆蛋白及精氨酸增加;除精氨酸水平升高外,正常大鼠经精氨酸治疗后上述其他参数无变化。结论精氨酸可以有效改善糖尿病之多饮、多食症状,但对血糖及体质量无影响。 

Abstract: Objective To observe the effect of L-arginine on diabetic rats. Methods Forty adult male Lewis rats were randomized equally into diabetic and normal control groups, and the former rats were treated intraperitoneally with streptozotocin to induce diabetes mellitus. Seven days later, half of the diabetic and normal rats were injected intraperitoneally with L-arginine at the daily dose of 1 g/kg, while the remainder were given saline instead. All the rats were euthanized on 10 days after L-arginine or saline treatment, and their body weight, plasma protein, arginine and sugar, food and water intake were analyzed. Results Diabetic rats had obviously decreased body weight, plasma protein and arginine but increased blood sugar and food and water intakes in comparison with the control rats. L-arginine significantly increased plasma protein and arginine, decreased food and water intakes, but failed to prevent weight loss and blood sugar increment in diabetic rats as compared to their saline-treated counterparts. L-arginine supplementation did not result in any changes other than arginine elevation in the control rats. Conclusion L-arginine supplementation can partially improve polydipsia and polyphagia and increase plasma protein in diabetic rats.

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