南方医科大学学报

南方医科大学学报 ›› 2006, Vol. 26 ›› Issue (09): 1307-1310.

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VEGF-C和MMP-2蛋白表达对非小细胞肺癌预后的影响

张惠忠； 魏益平； 李海刚； 王梅； 刘金耿； 吴澄；   

  1. 中山大学附属第二医院心胸外科； 中山大学附属第二医院病理科； 中山大学附属第二医院心胸外科 广东广州510120； 广东广州510120；
  • 出版日期:2006-09-20 发布日期:2006-09-20
  • 基金资助:
    广州市科委科技攻关引导项目(02Z3-E0016)~~

Expressions of vascular endothelial growth factor C and matrix metalloproteinases-2 and prognosis of non-small cell lung carcinoma

ZHANG Hui-zhong1, WEI Yi-ping1, LI Hai-gang2, WANG Mei1, LIU Jin-geng1, WU Cheng1 Departments of Cardiothoracic Surgery1 and Pathology2, Second Affiliated Hospital, Sun Yat-sen University, Guangzhou 510120, China   

  1. 中山大学附属第二医院心胸外科； 中山大学附属第二医院病理科； 中山大学附属第二医院心胸外科 广东广州510120； 广东广州510120；
  • Online:2006-09-20 Published:2006-09-20

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摘要： 目的研究血管内皮生长因子-C(VEGF-C)和基质金属蛋白酶-2(MMP-2)蛋白在非小细胞肺癌(NSCLC)组织中的表达及其与肺癌生物学行为的关系。方法应用免疫组化方法检测42例NSCLC组织中VEGF-C和MMP-2蛋白的表达情况,分析其与肿瘤大小、肿瘤淋巴管密度、组织类型、分化程度、临床分期、临床复发、淋巴结转移情况和术后生存时间的关系。结果42例NSCLC组织中,有23例VEGF-C蛋白表达呈阳性,阳性表达率为54.8%;有26例MMP-2蛋白表达呈阳性,阳性表达率为61.9%。VEGF-C蛋白的表达与淋巴管密度、淋巴结转移呈正相关(P<0.05),与组织分化程度、患者术后生存时间呈负相关(P<0.05)。MMP-2蛋白的表达与NSCLC的淋巴结转移正相关(P<0.05),与患者术后生存时间呈负相关(P<0.05)。VEGF-C和MMP-2蛋白的表达之间呈正相关(r=0.469,P<0.05)。结论VEGF-C和MMP-2蛋白的表达与NSCLC的生物学行为具有相关性,它们的高表达提示NSCLC患者容易出现淋巴结转移和预后不良。

Abstract: Objective To investigate the expressions of vascular endothelial growth factor-C (VEGF-C) and matrix metalloproteinases-2 (MMP-2) proteins and its relationship with the biological behaviors of non-small cell lung carcinoma (NSCLC). Methods Immunohistochemical staining was used to detect the expressions of VEGF-C and MMP-2 proteins in 42 cases of NSCLC tissues. The relationship of VEGF-C and MMP-2 expressions was analyzed with the tumor size, lymphatic vessel density (LVD), histological type, differentiation, clinical recurrence, lymph node metastasis and patients’ survival time. Results Out of the 42 cases of NSCLC, 23 and 26 cases showed positive expressions of VEGF-C and MMP-2 proteins, respectively, with the expression rates of VEGF-C and MMP-2 protein of 54.8% and 61.9%, respectively. VEGF-C expression was positively associated with LVD and lymph node metastasis (P<0.05), and inversely with the differentiation of NSCLC and the patients’ survival time (P<0.05). MMP-2 expression was positively associated with lymph node metastasis (P<0.05) and inversely with the patients’ survival (P<0.05). VEGF-C and MMP-2 expressions was positively associated (r=0.469, P<0.05). Conclusion The expressions of VEGF-C and MMP-2 proteins are closely associated with the biological behaviors of NSCLC, and their high expression suggests probable lymph node metastasis and poor prognosis. 

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