南方医科大学学报

南方医科大学学报 ›› 2006, Vol. 26 ›› Issue (08): 1227-1229.

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IVF-ET周期中glycodelin与子宫内膜容受性及妊娠关系的初步研究

刘红梅； 邢福祺； 吴凤林；   

  1. 南方医科大学南方医院超声诊断科； 南方医科大学南方医院生殖中心； 南方医科大学南方医院超声诊断科 广东广州510515； 广东广州510515；
  • 出版日期:2006-08-20 发布日期:2006-08-20

Glycodelin in IVF-ET cycles: its association with endometrial receptivity and impact on the outcome of pregnancy

LIU Hong-mei1, XING Fu-qi2, WU Feng-lin1 1Department of Ultrasound Diagnosis, 2Assisted Reproduction Center, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China   

  1. 南方医科大学南方医院超声诊断科； 南方医科大学南方医院生殖中心； 南方医科大学南方医院超声诊断科 广东广州510515； 广东广州510515；
  • Online:2006-08-20 Published:2006-08-20

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摘要： 目的探讨IVF-ET周期中,取卵日和ET日血清glycodelin水平与子宫内膜容受性之间的关系及其对妊娠结局的影响。方法ELISA方法检测IVF-ET患者取卵日和ET日血清glycodelin水平,同时经阴道超声评价子宫内膜情况。结果取卵日或ET日妊娠组与未妊娠组血清glycodelin水平相比无差异,但妊娠组ET日与取卵日血清glycodelin水平的比值和差值均明显高于未妊娠组(分别为2.54±2.14vs0.96±0.51,0.91±1.22vs-0.30±1.14);血清glycodelin水平与子宫内膜的厚度和回声类型无关。结论取卵日和ET日血清glycodelin水平与其子宫内膜厚度和回声类型无关,取卵日和ET日血清glycodelin水平的动态变化一定程度上反映了子宫内膜的容受性,对IVF-ET后妊娠结局的预测具有参考价值。 

Abstract: Objective To investigate the correlation between glycodelin and endometrial receptivity and the value of serum glycodelin detection in in vitro fertilization and embryo transfer (IVF-ET) cycles for evaluation of the outcome of pregnancy. Methods Serum glycodelin level in women receiving IVF-ET on the day of oocyte retrieval and embryo transfer was measured by ELISA, and the condition of the endometrium was examined by transvaginal ultrasonography. Results There was no difference in serum glycodelin level on the day of oocyte retrieval or embryo transfer between the pregnant group and nonpregnant group, but the ratio and difference of serum glycodelin levels on the days of embryo transfer and retrieval were both higher in pregnant group than in the nonpregnant group (2.54±2.14 vs 0.96±0.51, and 0.91±1.22 vs -0.30±1.14, respectively). No correlation was found between serum glycodelin levels and endometrial thickness or echo patterns. Conclusion Serum glycodelin levels on the days of retrieval and embryo transfer are not correlated to endometrial thickness or echo patterns, but their dynamic changes reflect endometrial receptivity to a certain extent, which might have prognostic value for pregnancy following IVF-ET.

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