南方医科大学学报

南方医科大学学报 ›› 2006, Vol. 26 ›› Issue (08): 1170-1172.

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宫颈癌中顺铂放疗增敏的临床药代动力学机制

卢金利； 杨芳；   

  1. 西安交通大学第一医院肿瘤放疗科； 西安交通大学西区图书馆 陕西西安710061； 陕西西安710061；
  • 出版日期:2006-08-20 发布日期:2006-08-20
  • 基金资助:
    陕西省科技攻关项目(2005k09-G5)~~

Clinical pharmacokinetic study of cisplatin in enhancing cervical cancer radiosensitivity

LU Jin-li1, YANG Fang2 Department of Radiotherapy, First Hospital1, Western District Library2, Xi’an Jiaotong University, Xi’ an 710061, China   

  1. 西安交通大学第一医院肿瘤放疗科； 西安交通大学西区图书馆 陕西西安710061； 陕西西安710061；
  • Online:2006-08-20 Published:2006-08-20

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摘要： 目的探讨在巨块型宫颈癌放疗中顺铂作为放射增敏剂用药最佳时机,从而指导临床放疗。方法将36例Ⅰa-Ⅱb期巨块型宫颈癌患者放疗前行增敏剂量顺铂(30mg/m2)静脉点滴,随机在1、2、4、6、10、18、24h时间点,抽取患者静脉血并行宫颈肿瘤区活检,同时对不同放疗剂量后的宫颈癌患者行顺铂(30mg/m2)静脉点滴,在4h时间点行宫颈肿瘤区活检,利用石墨炉原子吸收法测定血浆和肿瘤组织中的顺铂含量。结果肿瘤组织中的顺铂含量在4h时间点浓度最高,静脉血中的顺铂含量在2h内下降明显。放疗不同剂量肿瘤组织中的顺铂含量不同,而且与剂量成正相关。结论肿瘤组织中顺铂含量在静脉注射后4h达高峰,放疗应在此时进行,增敏效果可能最好。肿瘤放疗后期行顺铂放射增敏效果可能好于早期增敏。 

Abstract: Objective To valuate the pharmacokinetics of cisplatin in enhancing the radiosensitivity of stageⅡa-Ⅱb bulky cervical cancer. Methods Thirty-six patients with stageⅡa-Ⅱb bulky cervical cancer were treated intravenously with cisplatin (30 mg/m2) and cisplatin levels were measured in tumor tissues and serum of the patients at the random time points of 1, 2, 4, 6, 10, 18, and 24 h following the injection. Cisplatin levels were also measured in the tissues following administration of different radiation doses by flameless atomic absorption spectrometry. Results Cisplatin level in the tumor tissues was the highest at 4 h following the injection, and its serum level showed obvious reduction within 2 h following the injection. Radiation increased cisplatin level in the tumor tissue. Conclusion Cisplatin level reaches the highest level in the cancer tissue at 4 h following intravenous injection, a time when cisplatin can best execute its effect in enhancing the radiosensitivity of cervical cancer, and cisplatin administration in later stage of radiotherapy may achieve better effect than early stage administration. 

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