南方医科大学学报

南方医科大学学报 ›› 2006, Vol. 26 ›› Issue (08): 1163-1165.

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广东妇女子宫内膜异位症与肿瘤坏死因子-β基因多态性的相关性研究

罗敏； 何援利； 张宏斌； 申东翔； 宗利丽； 关婷；   

  1. 广州军区广州总医院妇产科； 南方医科大学珠江医院妇产科； 广州军区广州总医院妇产科 广东广州510010； 广东广州510282； 广东广州510010；
  • 出版日期:2006-08-20 发布日期:2006-08-20

Association of tumor necrosis factors-β gene polymorphism with endometriosis in women in Guangdong Province

LUO Min1, HE Yuan-li2, ZHANG Hong-bin1, SHEN Dong-xiang1, ZONG Li-li2, GUAN Ting1 1Department of Obstetrics and Gynecology, Guangzhou General Hospital of Guangzhou Command, Guangzhou 510010, China; 2Department of Obstetrics and Gynecology, Zhujiang Hospital, Southern Medical University, Guangzhou 510282, China   

  1. 广州军区广州总医院妇产科； 南方医科大学珠江医院妇产科； 广州军区广州总医院妇产科 广东广州510010； 广东广州510282； 广东广州510010；
  • Online:2006-08-20 Published:2006-08-20

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摘要： 目的研究子宫内膜异位症(内异症)患者及非内异症妇女TNF-β基因+252位点的多态性,探讨TNF基因多态性与内异症的遗传易感性的关系,力求在基因水平上探讨内异症发病的机制,以求找到治疗内异症的根本切入点。方法应用聚合酶链反应-限制性片段长度多态性技术(PCR-RFLP技术)检测82例内异症患者(内异症组)80例非内异症妇女(对照组)TNF-β基因+252位点的多态性。两组妇女均为广东籍。结果TNF-β+252位点等位基因及基因型分布在内异症组和对照组间差异显著(χ2=6.562,P<0.05;χ2=6.562,P<0.05),其中等位基因A使患内异症的相对危险度提高了1.793倍。携带AA基因型的个体患内异症的风险是GG基因型的3.33倍(χ2=6.562,P<0.05)。结论TNF-β基因+252位点上等位基因A可以使广东妇女患内异症的相对危险度明显提高。TNF-βAA基因型可能是广东地区汉族妇女内异症的遗传易感因素之一 

Abstract: Objective To study the polymorphism of +252 site in intron 1 of tumor necrosis factor (TNF)-β gene in relation to genetic susceptibility of endometriosis. Methods Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was employed to detect the polymorphism of +252 site in intron 1 of TNF-β gene in 82 Chinese Han patients with endometriosis in Guangdong Province and 80 Han patients without endometriosis (control group), and the relation between TNF gene polymorphism and the risk of endometriosis was analyzed. Results The +252 site of TNF-β allele and genotype distribution showed significant difference between endometriosis and control groups (χ2=6.562, P<0.05; χ2=6.562, P<0.05), and relative risk of endometriosis in relation to allele A was increased by 1.793 fold. The risk of endometriosis was 3.33-fold higher in women of AA genotype than those of GG genotype (χ2=6.562, P<0.05). Conclusions Allele A in TNF-β gene +252 site can significantly increase the relative risk of endometriosis in women in Guangdong, among which TNF-β AA genotype might be one of the genetic susceptible factors for endometriosis. 

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