南方医科大学学报

南方医科大学学报 ›› 2006, Vol. 26 ›› Issue (08): 1146-1148.

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他扎罗汀对进行期银屑病增殖表皮中早幼粒细胞白血病基因的抑制作用

王琼玉； 阎呼玲； 刘平； 彭振辉； 谭升顺；   

  1. 西安交通大学医学院附属二院皮肤科； 西安交通大学医学院附属二院皮肤科 陕西西安710004； 陕西西安710004；
  • 出版日期:2006-08-20 发布日期:2006-08-20
  • 基金资助:
    国家自然科学基金(30371295);陕西省自然科学基金(2002C236)~~

Inhibition of promyelocytic leukemia gene by tazarotene in hyperproliferative epidermis of psoriasis

WANG Qiong-yu, YAN Hu-ling, LIU Ping, PENG Zhen-hui, TAN Sheng-shun Department of Dermatology, Second Hospital of Xi’an Jiaotong University, Xi’an 710004, China   

  1. 西安交通大学医学院附属二院皮肤科； 西安交通大学医学院附属二院皮肤科 陕西西安710004； 陕西西安710004；
  • Online:2006-08-20 Published:2006-08-20

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摘要： 目的探讨他扎罗汀在进行期寻常型银屑病中的作用机制。方法将43例进行期寻常型银屑病患者随机分为他扎罗汀治疗组及对照组,用原位杂交的方法检测进行期银屑病皮损外用他扎罗汀治疗前后的早幼粒细胞白血病(PML)基因mRNA的表达。结果在银屑病治疗组皮损中,可见PML不仅表达于基底层(86.96%),且以灶状表达于基底上层(78.26%);他扎罗汀治疗后14d全层几乎无PMLmRNA表达(基底层为8.69%,基底上层为4.35%)。对照组处理前后PML基因表达无明显变化。结论他扎罗汀可能通过下调进行期银屑病表皮中PML基因的表达来抑制表皮角质形成细胞的异常增殖。 

Abstract: Objective To investigate the mechanism of tazarotene against active psoriasis vulgaris. Methods A randomized, controlled trial was conducted in 43 patients with active psoriasis vulgaris, who were divided into tazarotene and control groups. Promyelocytic leukemia (PML) mRNA in active psoriatic lesions before and 14 days after tazarotene treatment was detected by in situ hybridization. Results PML mRNA expression was detected not only in the basal layer (86.96%), but also in the suprabasal layers of the epidermis in the manner of focal expression (78.26%). After tazarotene treatment, virtually no PML mRNA expression could be detected in the psoriatic lesions (8.69% in the basal layer and 4.35% in the suprabasal layers). PML mRNA expression in the control group underwent no obvious changes during the observation. Conclusions Tazarotene may inhibit abnormal proliferation of keratinocytes through down-regulating PML gene expression in active psoriatic epidermis. 

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