南方医科大学学报

南方医科大学学报 ›› 2006, Vol. 26 ›› Issue (08): 1140-1142.

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不同分化程度鼻咽癌细胞化疗药物作用后放射敏感性的变化

卜俊国； 张积仁； 肖明星；   

  1. 南方医科大学珠江医院肿瘤中心； 南方医科大学珠江医院肿瘤中心 广东广州510282； 广东广州510282；
  • 出版日期:2006-08-20 发布日期:2006-08-20
  • 基金资助:
    国家自然科学基金(30270424)~~

Radiosensitivity changes of nasopharyngeal carcinoma cells with different levels of differentiation after treatment with chemotherapeutic agents

BU Jun-guo, ZHANG Ji-ren, XIAO Ming-xing Oncology Center, Zhujiang Hospital, Southern Medical University, Guangzhou 510282, China   

  1. 南方医科大学珠江医院肿瘤中心； 南方医科大学珠江医院肿瘤中心 广东广州510282； 广东广州510282；
  • Online:2006-08-20 Published:2006-08-20

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摘要： 目的检测鼻咽高分化鳞癌细胞系CNE1和低分化鳞癌细胞系CNE2细胞化疗药物作用后放射敏感性的变化。方法对CNE1和CNE2细胞以及经阿霉素作用后的细胞射线照射,应用集落形成实验方法绘制细胞存活曲线,得出放射生物学参数,比较化疗药物作用后细胞放射敏感性的变化。结果CNE1细胞化疗药物作用后放射敏感性增高;而CNE2细胞化疗药物作用后放射敏感性降低。结论临床上对中晚期鼻咽癌的治疗应根据其不同病理类型考虑个体化治疗方案。 

Abstract: Objective To examine the changes of radiosensitivity of CNE1, a well differentiated squamous cell line of nasopharyngeal carcinoma (NPC), and CNE2, a poorly differentiated squamous cell line of NPC, after treatment with chemotherapeutic agents. Methods CNE1 and CNE2 cells with and without treated by adriamycin (ADM) were irradiated by X-ray and the radiosensitivity changes of ADM-treated cells were analyzed according to the cell survival curve generated by colony formation assay. Result and Conclusion Radiosensitivity of CNE1 cells increased after ADM treatment, but that of CNE2 cells decreased, suggesting that different treatment regimens should be planned for advanced squamous cell NPC of different pathological types.

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