南方医科大学学报 ›› 2006, Vol. 26 ›› Issue (07): 1020-1022.

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习惯性流产的病毒病因探讨

蒋文玲; 刘钊; 杨占秋; 徐顺先; 罗宪玲;   

  1. 广东省人民医院医学研究中心; 武汉大学医学院病毒研究所; 武汉大学人民医院; 广东省人民医院医学研究中心 广东广州510080; 湖北武汉430071; 湖北武汉430060; 广东广州510080;
  • 出版日期:2006-07-20 发布日期:2006-07-20

Investigation of viral pathogens contributing to habitual abortion

JIANG Wen-ling1, LIU Zhao2, YANG Zhan-qiu2, XU Shun-xian3, LUO Xian-ling1 1Medical Reseach Center, People’s Hospital of Guangdong Province, Guangzhou 510080, China; 2Institute of Virology, Medical College of Wuhan University, Wuhan 430071, China; 3People’s Hospital of Wuhan University, Wuhan 430060, China   

  1. 广东省人民医院医学研究中心; 武汉大学医学院病毒研究所; 武汉大学人民医院; 广东省人民医院医学研究中心 广东广州510080; 湖北武汉430071; 湖北武汉430060; 广东广州510080;
  • Online:2006-07-20 Published:2006-07-20

摘要: 目的用多种技术方法研究探讨柯萨奇B组病毒(CBV)与习惯性流产的病毒病因。方法采用ELISA、RT-PCR和病毒分离对86例习惯性流产和40例人工流产妇女进行了CBV-IgM抗体、病毒RNA和病毒粒子检测。结果检测结果表明习惯性流产和人工流产两组妇女柯萨奇B组病毒IgM阳性率分别为87.2%和35.0%,血淋巴细胞CBVRNA阳性率则为53.5%和17.5%;而胎盘组织中病毒RNA阳性率各为59.3%和17.5%,胎盘组织中病毒分离阳性率在两组妇女各为41.9%和6.9%。其各项指标经!2检验,两组均有显著性差异(P<0.01)。结论柯萨奇B组病毒可能是习惯性流产的发生因素之一。 

Abstract: Objective To investigate the association of Coxsackie B virus (CBV) with habitual abortion. Methods CBV IgM antibody, viral RNA and virions were detected in 86 women with habitual abortion and 40 with induced abortion by means of enzyme-linked immunosorbent assay (ELISA), RT-PCR and virus isolation, respectively. Results The positivity rate of CBV IgM were 87.2% and 35% in the two groups, respectively, and the detection rate of the viral RNA was 53.5% and 17.5% in blood lymphocytes, and 59.3% and 17.5% in the placentas. The virions were found in the placentas in 41.9% and 6.9% of the women, respectively. The positiivty rates of CBV IgM, viral DNA and virions showed significant difference between the two groups (P<0. 01). Conclusion CBV might be one of the causes responsible for habitual abortion. 

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