南方医科大学学报

南方医科大学学报 ›› 2006, Vol. 26 ›› Issue (06): 858-859.

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血清神经元特异烯醇化酶临界值在鉴别小细胞肺癌与非小细胞肺癌中的作用

魏涛； 罗荣城； 左强； 张军一； 缪景霞； 卢惠芳；   

  1. 南方医科大学南方医院肿瘤中心； 南方医科大学南方医院肿瘤中心 广东广州510515； 广东广州510515；
  • 出版日期:2006-06-20 发布日期:2006-06-20

Role of the cut-off value of serum neuron-specific enolase in differentiating small cell lung cancer from non-small cell lung cancer

WEI Tao, LUO Rong-cheng, ZUO Qiang, ZHANG Jun-yi, MIAO Jing-xia, LU Hui-fang Center of Oncology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China   

  1. 南方医科大学南方医院肿瘤中心； 南方医科大学南方医院肿瘤中心 广东广州510515； 广东广州510515；
  • Online:2006-06-20 Published:2006-06-20

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摘要： 目的通过较大样本血清神经元特异烯醇化酶(NSE)的检测,确定鉴别小细胞肺癌(SCLC)与非小细胞肺癌(NSCLC)NSE血清水平临界值。方法酶联免疫吸附法检测137例经病理证实的肺癌患者NSE血清水平,应用ROC曲线确定鉴别SCLC与NSCLC的最佳临界值。结果SCLC组血清NSE阳性率显著高于NSCLC组(P<0.01),应用ROC曲线确定NSE的最佳临界值为15.45μg/L;在此临界值下,NSE鉴别SCLC与NSCLC的敏感性为66.7%,特异性为65.7%。结论检测血清NSE水平可以作为鉴别SCLC与NSCLC的指标之一,具有一定的临床应用价值。 

Abstract: Objective To determine the cut-off value of serum neuron-specific enolase (NSE) level for distinguishing small cell lung cancer (SCLC) and non-small cell lung cancer (NSCLC). Methods Serum NSE levels were measured by enzyme-linked immunosorbent assay in 137 patients with NSCLC or SCLC, and the best cut-off value was analyzed using ROC curve. Results The positivitity rate of serum NSE was significantly higher in patients with SCLC than in those with NSCLC (P<0.01). The best cut-off value was 15.45 μg/L using ROC curve, which gave a sensitivity of 66.7% and specificity of 65.7%. Conclusion Serum NSE level may allow simple and cost-effective differentiation of SCLC and NSCLC. 

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