南方医科大学学报

南方医科大学学报 ›› 2006, Vol. 26 ›› Issue (06): 844-846.

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动态监测血清β-绒毛膜促性腺激素对异位妊娠早期诊断的价值

黄英源； 邓敏端； 赵翠柳； 区海；   

  1. 暨南大学第四附属医院/广州市红十字会医院妇产科； 暨南大学第四附属医院/广州市红十字会医院妇产科 广东广州510220； 广东广州510220；
  • 出版日期:2006-06-20 发布日期:2006-06-20

Dynamic monitoring of serum human chorionic gonadotropin β-subunit levels for early diagnosis of ectopic pregnancy

HUANG Ying-yuan, DENG Min-duan, ZHAO Cui-liu, OU Hai Department of Obstetrics and Gynecology, Guangzhou Red-Cross Hospital/Forth Affiliated Hospital of Jinan University, Guangzhou 510220, China   

  1. 暨南大学第四附属医院/广州市红十字会医院妇产科； 暨南大学第四附属医院/广州市红十字会医院妇产科 广东广州510220； 广东广州510220；
  • Online:2006-06-20 Published:2006-06-20

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摘要： 目的动态监测异位妊娠患者血清β-绒毛膜促性腺激素(β-HCG),探讨其变化对早期诊断异位妊娠的价值。方法选取106例早期异位妊娠患者作为研究组,以同期就诊的先兆流产患者69例作为对照组。采用化学发光法对患者血β-HCG进行动态监测,隔2-3d复查血β-HCG。结果(1)异位妊娠组不同的停经天数初次血β-HCG的均值均明显低于对照组(P<0.05),但两组患者血β-HCG波动幅度都比较大,存在较大的重叠区域。(2)异位妊娠组不同的停经天数血β-HCG递增倍数(HCG2/HCG1)均显著低于对照组(P<0.05)。结论单次血β-HCG检测对异位妊娠与先兆流产的鉴别诊断价值有限,不能凭单次血β-HCG检测来判断是否为异位妊娠。动态监测血β-HCG变化规律可作为诊断早期异位妊娠的重要依据,临床分析时应结合阴道B超结果及停经天数综合考虑。 

Abstract: Objective To assess the value of monitoring serum human chorionic gonadotropin β-subunit (β-HCG) level changes in early diagnosis of ectopic pregnancy. Methods Totalling 106 cases of ectopic pregnancy and 69 cases of threatened abortion were included in the study. Blood samples were collected to examine β-HCG levels, which was repeated 2-3 days later. Results Initial serum β-HCG levels of the women with ectopic pregnancy and different were significantly lower than those in women with threatened abortion (P<0.05), and the increatment rate of serum β-HCG in the former was also significantly lower (P<0.05). Conclusion Compared with single-time serum β-HCG detection, dynamic monitoring of serum β-HCG provides more important and reliable evidence for early diagnosis of ectopic pregnancy. Transvaginal ultrasonogrophy and in should also be considered in the clinical analysis. 

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