南方医科大学学报

南方医科大学学报 ›› 2006, Vol. 26 ›› Issue (06): 831-.

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长沙地区女性泌尿生殖道支原体感染状况及药敏分析

左成忻； 黄进华； 陈静； 鲁建云； 向亚平；   

  1. 中南大学湘雅三医院皮肤科； 中南大学湘雅三医院皮肤科 湖南长沙410013； 湖南长沙410013；
  • 出版日期:2006-06-20 发布日期:2006-06-20

Female urogenital mycoplasma infection and drug sensitivity status in Changsha

ZUO Cheng-xin, HUANG Jin-hua, CHEN Jin, LU Jian-yun, XIANG Ya-ping Department of Dermatology, Third Xiangya Hospital of Central South University, Changsha 410013, China   

  1. 中南大学湘雅三医院皮肤科； 中南大学湘雅三医院皮肤科 湖南长沙410013； 湖南长沙410013；
  • Online:2006-06-20 Published:2006-06-20

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摘要： 目的探讨长沙地区女性泌尿生殖道支原体感染及对药物的敏感情况。方法使用支原体培养及药敏试剂盒检测6566例女性泌尿生殖道的解脲支原体(Uu)和人型支原体(Mh),并对10种抗生素的药敏试验进行分析。结果2938例检测出支原体,阳性率为44.75%,其中Uu2469例(37.60%),Mh52例(0.08%),Uu合并Mh417例(6.35%)。Uu对交沙霉素、强力霉素、克拉霉素和阿齐霉素较为敏感;Mh对交沙霉素、强力霉素和甲砜霉素较为敏感;Uu合并Mh感染对多种药物有较高的耐药性,但对交沙霉素和强力霉素敏感。结论长沙地区女性泌尿生殖道支原体感染以Uu为主,Uu感染和Mh感染与Uu合并Mh感染对药物的耐受性有明显差异,Uu合并Mh感染增强了对药物的耐受性,扩大了耐药范围。交沙霉素和强力霉素是长沙地区女性泌尿生殖道支原体感染的首选药物。 

Abstract: Objective To survey mycoplasma infection in female urogenital tract and analyze the drug sensitivity of mycoplasma in Changsha. Methods Ureaplasma urealyticum (Uu) and Mycoplasma hominis (Mh) were detected in 6566 cases of female urogenital tract infection by means of mycoplasma culture and drug sensitivity reagent kit. Sensitivity tests for 10 antibiotics were also performed. Results A total of 2938 cases were mycoplasma-positive (positivity rate of 44.75%), including 2469 Uu-positive cases (37.6%), 52 Mh-positive cases (0.08%) and 417 cases positive for both Uu and Mh (6.35%). Josamycin, doxycycline, clarithromycin and azithromycin were more effective against Uu infection. Josamycin, doxycycline and thiamphenicol were more effective against Mh infection. Mixed infection with Uu and Mh was more resistant to most antibiotics but Josamycin and doxycycline. Conclusions The female urogenital mycoplasma infection results mainly from Uu. Compared with simple Uu or Mh infection, mixed infection with Uu and Mh has significantly greater resistance to a wider variety of drugs. Josamycin and doxycycline are the primary choice for female urogenital mycoplasma infection in Changsha. 

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