南方医科大学学报

南方医科大学学报 ›› 2006, Vol. 26 ›› Issue (06): 785-787.

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激素性股骨头坏死股骨头微血管的变化

胡志明； 王海彬； 周明乾； 姚新生； 马骊； 王小宁；   

  1. 南方医科大学分子免疫学研究所； 广州中医药大学第一附属医院骨科； 南方医科大学分子免疫学研究所 广东广州510515； 广东广州510405； 广东广州510515；
  • 出版日期:2006-06-20 发布日期:2006-06-20
  • 基金资助:
    广州市科技计划项目(2003Z2-E0171);广东省科技攻关计划项目(2004B31201010);军队医药卫生科研基金(04LX028)~~

Pathological changes of the blood vessels in rabbit femoral head with glucocorticoid-induced necrosis

HU Zhi-ming1, WANG Hai-bin2, ZHOU Ming-qian1, YAO Xin-sheng1, MA Li1, WANG Xiao-ning1 1Institute of Molecular Immunology, Southern Medical University, Guangzhou 510515, China; 2Department of Orthopedic Surgery, First Affiliated Hospital of Guangzhou University of Traditional Chinese Medicine and Pharmacology, Guangzhou 510405, China   

  1. 南方医科大学分子免疫学研究所； 广州中医药大学第一附属医院骨科； 南方医科大学分子免疫学研究所 广东广州510515； 广东广州510405； 广东广州510515；
  • Online:2006-06-20 Published:2006-06-20

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摘要： 目的通过观察激素性股骨头坏死股骨头微血管的变化,探讨股骨头缺血性坏死的机制。方法将20只健康新西兰兔随机分成两组,每组10只。A组:模型组,注射马血清及醋酸泼尼松龙造模;B组:正常对照组,采用墨汁灌注及病理组织切片对股骨头的微循环结构及组织细胞的病理变化进行观察。结果墨汁灌注结果显示:模型组股骨头血管显著减少,灌注不全面,血管出现明显栓塞。病理组织切片HE染色显示:骨细胞核固缩,部分血管栓塞,骨髓腔内造血组织明显减少。结论大剂量激素引起的微血管内皮损伤,血管栓塞,可能是造成股骨头坏死的重要原因。 

Abstract: Objective To observe the pathological changes in the blood vessels in rabbit femoral head with glucocorticoid-induced necrosis and investigate the pathogenesis of glucocorticoid-induced osteonecrosis. Methods Twenty New Zealand white rabbits were randomly divided into two groups, namely group A. which was injected with horse serum and prednisone and group B as the control group. Chinese ink was injected into the femoral cavity of the rabbits to observe the blood vessels in the femoral head under optical microscope and the femoral head was examined histopathologically. Results Compared with the normal control group, the rabbits in group A had significantly decreased number of perfused vessels, which was featured by defective perfusion, osteocytie pyknosis or necrosis, increase of empty ostoocyte lacunae and fat cells, decrease of hematopoietic tissue, and blood vessel occlusion. Conclusion Vascular occlusion and vasculitis due to glucocorticoid treatment may cause avascular necrosis of the femoral head.

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