南方医科大学学报

南方医科大学学报 ›› 2006, Vol. 26 ›› Issue (05): 699-700.

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基质金属蛋白酶组织抑制因子-1在大肠癌中的表达

刘旸； 姜泊； 童华生； 赖晓嵘；   

  1. 南方医科大学南方医院消化研究所； 南方医科大学南方医院消化研究所 广东广州510515； 广东广州510515；
  • 出版日期:2006-05-20 发布日期:2006-05-20

Expression of tissue inhibitor of metalloproteinase-1 in colorectal carcinoma and its clinical implications

LIU Yang,JIANG Bo,TONG Hua-sheng,LAI Xiao-rong Department of Gastroenterology,Nanfang Hospital,Southern Medical University,Guangzhou 510515,China   

  1. 南方医科大学南方医院消化研究所； 南方医科大学南方医院消化研究所 广东广州510515； 广东广州510515；
  • Online:2006-05-20 Published:2006-05-20

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摘要： 目的探讨基质金属蛋白酶组织抑制因子-1(TIMP-1)在大肠癌中的表达及临床意义。方法采用免疫组化S-P法对54例大肠癌组织的TIMP-1进行检测,结合临床资料进行分析。结果TIMP-1主要表达于大肠上皮细胞膜和细胞浆,正常大肠组织表达率为100%,在大肠癌组织的表达率为59.6%(31/52),且淋巴结转移大肠癌组表达低于无淋巴结转移组(P<0.05)。结论TIMP-1的表达程度与大肠癌淋巴结转移呈负相关,TIMP-1的表达程度降低在大肠癌病程演进中可能发挥一定的作用。 

Abstract: Objective To investigate the expression and clinical implication of tissue inhibitor of metalloproteinase-1(TIMP-1)in colorectal carcinoma.Methods TIMP-1 expression in 54 colorectal carcinoma was observed by SP immunohistochemical method,and the results were analyzed in relation to the clinical data of patients.Results TIMP-1 was localized on the membrane and in the cytoplasm of the enteric epithelial cells,and its expression rate was 100% in normal tissue but only 59.6%(31/52)in colorectal carcinoma tissues.In addition,the expression rate of TIMP-1 was higher in the tumor tissues without lymph node metastasis than in tissues with lymph node metastasis(P<0.05).Conclusion The expression of TIMP-1 is inversely correlated to lymph node metastasis of colorectal carcinoma,and decreased TIMP-1 expression may play a role in the progression of colorectal carcinoma. 

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