南方医科大学学报

南方医科大学学报 ›› 2006, Vol. 26 ›› Issue (05): 697-698.

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移植肾亚临床排斥反应早期诊治的临床意义

曾京华； 于立新； 罗汉宏； 王晓春； 王鑫； 房魏；   

  1. 解放军第421医院外一科； 南方医科大学南方医院肾移植科； 解放军第421医院外一科 广东广州510318； 广东广州510515； 广东广州510318；
  • 出版日期:2006-05-20 发布日期:2006-05-20

Clinical significance of early diagnose and treatment of subclinical renal allograft rejection

ZENG Jing-hua1,YU Li-xin2,LUO Han-hong1,WANG Xiao-chun1,WANG Xin1,FANG Wei1 1Department of Urology,421 Hospital of the Navy,Guangzhou 510318,China;2Department of Kidney Transplantation,Nanfang Hospital,Southern Medical University,Guangzhou 510515,China   

  1. 解放军第421医院外一科； 南方医科大学南方医院肾移植科； 解放军第421医院外一科 广东广州510318； 广东广州510515； 广东广州510318；
  • Online:2006-05-20 Published:2006-05-20

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摘要： 目的探讨对移植肾亚临床排斥反应进行早期诊断、早期治疗的临床意义。方法选择术后3个月无临床症状、肾功能正常的同种异体肾移植患者96例(男54例,女42例),平均年龄为37.5岁(17～58岁),以彩色多普勒检查结果为诊断依据,分为正常组和异常组(亚临床排斥组),异常组给予甲基强的松龙冲击治疗和调整免疫抑制剂的剂量,随访观察两组移植肾的存活率。结果经过3年的随访,两组病人移植肾的存活率无明显差异性。结论早期诊断和治疗移植肾亚临床排斥反应,对提高移植肾的长期存活率有重要的临床意义。 

Abstract: Objective To explore the clinical significance of early diagnose and treatment of subclinical renal allograft rejection.Methods Ninety-six renal allograft recipients(54 male and 42 female)with normal renal function aged 17 to 58 years(mean 37.5 years)were included in this study.Early subclinical rejection was diagnosed 3 months after the transplantation by color Doppler examination.Results Patients with early subclinical rejection were given methylpredisolone followed by adjustment of immunosuppressive regimens,and no difference was observed in 3-year survival rate between these patients and those with normal renal allograft findings.Conclusion Early diagnosis and treatment of subclical renal allograft rejection is significant to improve renal allograft survival rate. 

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