南方医科大学学报

南方医科大学学报 ›› 2006, Vol. 26 ›› Issue (04): 509-.

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四环素对侵袭性牙周炎血清抗牙龈卟啉菌抗体水平的影响

张秀琴； 谢敏； 张惠芳； 黄世光； 张颖；   

  1. 暨南大学医学院口腔医学系； 张家口沙岭子精神病院五官科； 暨南大学医学院口腔医学系 广东 广州 510632； 广东 广州 510632； 河北 张家口 075000；
  • 出版日期:2006-04-20 发布日期:2006-04-20

Mechanical periodontal treatment combined with tetracycline for aggressive periodontitis

ZHANG Xiu-qin, XIE Min, ZHANG Hui-fang, HUANG Shi-guang, ZHANG Ying Department of Conservative Dentistry, Medical School of Ji’nan University, Guangzhou 510632, China; Department of Stomatology, First People’s Hospital of Zhangjiakou, Zhangjiakou 075000, China   

  1. 暨南大学医学院口腔医学系； 张家口沙岭子精神病院五官科； 暨南大学医学院口腔医学系 广东 广州 510632； 广东 广州 510632； 河北 张家口 075000；
  • Online:2006-04-20 Published:2006-04-20

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摘要： 目的评价结合四环素的机械性牙周治疗对侵袭性牙周炎(AP)患者牙周附着水平、牙槽骨组织和血清抗牙龈卟啉菌(Pg)抗体亲和力水平的影响。方法研究对象由26例AP患者、20例牙周健康者组成。牙周治疗前及治疗3、6和12 个月后常规临床检查,记录牙周附着水平;治疗前及治疗3个月和6个月后拍摄全口曲面断层片,记录釉牙骨质界到骨缺陷底及釉牙骨质界到牙槽嵴顶的距离;治疗前后,实验检测所有受试者血清抗Pg抗体亲和力水平。亲和力通过二乙醇胺分离ELISA测定。结果结合四环素的机械性牙周治疗后,牙周附着水平有显著改善(P<0．01);釉牙骨质界到骨缺陷底的影像改变显著(P<0．05);其血清抗Pg表面抗原脂多糖抗体亲和力水平亦明显下降(P<0．01)。结论结合四环素的机械性牙周治疗对AP患者可获得满意的疗效。 

Abstract: Objective To evaluate the effect of mechanical penodontal treatment combined with tetracycline on periodontal attachment, distances of cementum-enamel junction (CEJ) to the bone defect bottom and to the alveolar crest, and avidity of serum IgG against Porphyromonas gingivalis (Pg) lipopolysaccharide (LPS) in patients with aggressive periodontitis. Methods Twenty-six patients with aggressive periodontitis were divided equally into two groups to receive mechanical periodontal treatment combined with tetracycline or exclusive mechanical periodontal treatment, with another 20 periodontally healthy subjects serving as the control group. In the two patient groups, routine clinical examination of the subjects was performed to record periodontal attachment level and distances of CEJ to the bottom of the bone defects and to the alveolar crest before and 3 and 6 months after the treatment. The avidity of serum IgG against Pg LPS was measured by ELISA with thiocyanate elution before and after periodontal treatment. Results Compared with patients with exclusive mechanical periodontal treatment, patients with combined treatments showed significant improvement in periodontal attachment level and the distance of CEJ to the bone defect bottom after the treatment (P<0.01 and P<0.05, respectively) with also significantly reduced avidity of serum IgG against Pg LPS (P<0.01). Conclusion Mechanical periodontal treatment combined with tetracycline produces favorable effects in patients with aggressive periodontitis. 

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