南方医科大学学报

南方医科大学学报 ›› 2006, Vol. 26 ›› Issue (04): 495-497.

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多频稳态诱发电位分析后半规管瘘对豚鼠听力及耳蜗形态学结构的影响

谢南屏； 陈国强； 严星； 舒斯云；   

  1. 南方医科大学珠江医院耳鼻咽喉科； 南方医科大学珠江医院神经科学研究所 广东 广州 510282； 广东 广州 510282；
  • 出版日期:2006-04-20 发布日期:2006-04-20
  • 基金资助:
    广东省科技计划项目(2001C31204)~~

Analysis of auditory steady-state response to multiple simultaneous stimuli and cochlea morphology in guinea pigs with posterior semicircular canal fistula

XIE Nan-ping, CHEN Guo-qiang, YANG Xing, SHU Si-yun Department of Otolaryngology, Institute of Neuroscience, Zhujiang Hospital, Southern Medical University, Guangzhou 510282, China   

  1. 南方医科大学珠江医院耳鼻咽喉科； 南方医科大学珠江医院神经科学研究所 广东 广州 510282； 广东 广州 510282；
  • Online:2006-04-20 Published:2006-04-20

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摘要： 目的探讨豚鼠后半规管造瘘后的听力情况。方法健康杂色豚鼠10只,左耳为实验耳,右耳为对照耳,左耳后半规管造瘘后分别进行多频听觉稳态诱发电位测试。测试状态为戊巴比妥钠镇静睡眠。结果载波频率为0．5 kHz、1 kHz、 2 kHz及4 kHz时,左耳多频听觉稳态诱发反应阈(dB SPL)分别为30．00±8．66、25．56±5．27、20．00±5．00和22．22±4．21; 右耳分别为35．56±5．27、27．78±10．93、18．89±3．33和21．11±3．33。左右耳同频率之间差异无统计学意义。结论单纯手术造成的较小的后半规管瘘管对听力无明显影响。 

Abstract: Objective To observe the changes of auditory steady-state response (ASSR) threshold in guinea pigs with posterior semicircular canal fistula. Methods In 10 guinea pigs, a window was opened in the posterior semicircular canal of the left ear with the right ear serving as the control for testing the ASSR under anesthesia with pentobarbital sodium. Results The mean and standard deviation of ASSR threshold (dB SPL) at 0.5, 1, 2, and 4 kHz in the left ear was 35.00±14.33, 25.50±12.37, 20.00±9.37 and 20.00±9.18, respectively, and was 31.00±16.19, 25.50±12.34, 18.00±6.96 and 18.50±6.71 in the right ear, respectively. Paired-sample t test showed no significant difference in the ASSR at the same frequency between the two ears. Conclusion Small fistula by surgery causes no significant hearing loss in guinea pigs.

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