南方医科大学学报

南方医科大学学报 ›› 2006, Vol. 26 ›› Issue (03): 367-368.

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肠易激综合征患者外周血雌激素孕激素及睾酮激素含量分析

崔楠； 吴保平； 吴赛珠；   

  1. 南方医科大学南方医院消化内科； 南方医科大学南方医院消化内科 广东广州510515； 广东广州510515；
  • 出版日期:2006-03-20 发布日期:2006-03-20

Association of peripheral blood estradiol,progesterone and testosterone levels with irritable bowel syndrome

CUI Nan,WU Bao-ping,WU Sai-zhu Department of Gastroenterology,Nanfang Hospital,Southern Medical University,Guangzhou 510515,China   

  1. 南方医科大学南方医院消化内科； 南方医科大学南方医院消化内科 广东广州510515； 广东广州510515；
  • Online:2006-03-20 Published:2006-03-20

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摘要： 目的检测肠易激综合征(irritable bowel syndrome,IBS)患者外周血中性激素水平,探讨IBS发病与外周血性激素的关系。方法对符合罗马Ⅱ标准的48例IBS患者及30例健康对照者的外周血中雌激素、孕激素和睾酮激素的水平用放射免疫r计数器测定,并用自动软件分析。结果对于男性IBS患者,其外周血中睾酮激素含量低于健康对照组(P<0.05),而雌激素、孕激素含量与健康对照组差异无显著性(P>0.05)。对于女性IBS患者,其外周血中雌激素含量低于健康对照组(P<0.05),而孕激素、睾酮激素含量与健康对照组差异无显著性(P>0.05)。结论男性IBS患者外周血中睾酮激素含量下降,女性IBS患者外周血中雌激素含量下降,提示IBS患者的发病可能与体内性激素水平紊乱有关。 更多还原

Abstract: Objective To investigate the relation of peripheral blood estradiol,progesterone and testosterone levels with irritable bowel syndrome(IBS).Methods Forty-eight patients with IBS identified according to Rome Ⅱ diagnostic criteria and 30 healthy subjects as controls were analyzed for peripheral blood sex hormone levels by radioimmunossay and corresponding software.Results In male patients with IBS,blood testosterone level was significantly lower than that of the control group(P<0.05),but blood estradiol and progesterone showed no significant differences between the two groups(P>0.05).In the female patients,blood estradiol level was significantly lower than that of the control group(P<0.05),whereas blood progesterone and testosterone levels had no significant differences between the two groups(P>0.05).Conclusion Peripheral blood testosterone level in male IBS patients and estradiol level in female patients are lower than those of healthy subjects,suggesting that IBS might be associated with blood sex hormone disorder.

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