南方医科大学学报

南方医科大学学报 ›› 2006, Vol. 26 ›› Issue (03): 344-347.

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胃癌HER-2/neu基因表达与预后的相关性

陈斌； 罗荣城； 崔斐； 钱新宇；   

  1. 南方医科大学南方医院肿瘤中心； 南方医科大学南方医院肿瘤中心 广东广州510515； 广东广州510515；
  • 出版日期:2006-03-20 发布日期:2006-03-20

Association of HER-2/neu expression with prognosis of gastric cancer

CHEN Bin,LUO Rong-cheng,Cui Fei,QIAN Xin-yu Oncology Center,Nanfang Hospital,Southern Medical University,Guangzhou 510515,China   

  1. 南方医科大学南方医院肿瘤中心； 南方医科大学南方医院肿瘤中心 广东广州510515； 广东广州510515；
  • Online:2006-03-20 Published:2006-03-20

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摘要： 目的研究胃癌人表皮生长因子受体(HER)-2/neu基因的表达与生存期的关系,探讨其作为胃癌预后指标的可行性。方法应用免疫组织化学方法检测103例胃癌标本HER-2/neu基因的表达,并将检测结果与患者的随访资料及临床病理参数进行综合分析。结果103例胃癌组织中HER-2/neu基因的阳性表达率为31.1%(32/103);HER-2/neu基因在胃良性病变和癌旁组织中均无表达;HER-2/neu基因表达与患者的性别、年龄、肿瘤大小、部位、分化程度均无相关性(P>0.05),而与肿瘤的浸润深度、临床分期、淋巴结转移、远处转移及患者的生存时间相关(P<0.05)。结论HER-2/neu基因与胃癌的浸润、转移及预后密切相关,可作为判断胃癌生物学行为和预后的重要参考指标。 更多还原

Abstract: Objective To investigate the association between the expression of human epidermal growth factor receptor(HER)-2/neu gene and prognosis of gastric cancer.Methods The expression of HER-2/neu in gastric cancer was detected by immunohistochemical technique and analyzed in relation with the follow-up and clinicopathologic data of the patients.Results Thirty-two of the 103 gastric cancer specimens(31.1 %) were positive for HER-2/neu,but whose expression was not found in benign gastric lesion and normal gastric mucosa.HER-2/neu expression was not correlated with the patients’ sex,age,tumor size and location or the degree of differentiation(P>0.05),but with the depth of invasion,clinical stage,lymph node and distant metastasis of the tumor and survival of the patients(P<0.05).Conclusion HER-2/neu expression is closely related to invasion,metastasis and prognosis of gastric cancer and can be used to evaluate the biological behavior and prognosis of gastric cancer.

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