南方医科大学学报

南方医科大学学报 ›› 2006, Vol. 26 ›› Issue (03): 335-338.

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兔VX2种植型肝癌模型动态磁共振张量成像的量化研究

徐绍斌； 全显跃； 孙希杰；   

  1. 佛山市南海平洲医院影像科； 南方医科大学珠江医院影像中心； 南方医科大学珠江医院影像中心 广东佛山528251； 广东广州510282；
  • 出版日期:2006-03-20 发布日期:2006-03-20
  • 基金资助:
    佛山市医学科研立项(2004410)~~

Preliminary quantitative study of dynamic magnetic resonance diffusion tensor imaging in rabbit models implanted with hepatic tumor grafts from VX2

XU Shao-bin1,QUAN Xian-yue2,SUN Xi-jie2 1Imaging Center,Pingzhou Hospital,Foshan 528251,China;2Imaging Center,Zhujiang Hospital,Southern Medical University,Guangzhou 510282,China   

  1. 佛山市南海平洲医院影像科； 南方医科大学珠江医院影像中心； 南方医科大学珠江医院影像中心 广东佛山528251； 广东广州510282；
  • Online:2006-03-20 Published:2006-03-20

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摘要： 目的探讨对兔VX2种植型肝癌模型的成瘤过程进行动态磁共振张量成像(DTI)量化研究的可行性及价值。方法在肿瘤植入后第14、18、22、26天分别对4组共16只新西兰大白兔VX2种植型肝癌模型和4组共4只正常新西兰大白兔进行磁共振成像及DTI;动态量化分析平均弥散系数(ADC)、指数弥散系数(eADC)的变化规律并与病理结果对照。结果兔VX2种植型肝癌模型的ADC呈先递增后递减趋势;eADC呈先递减后递增趋势;与对照组间存在显著性差异;病理结果的多项分析中,瘤内凝固性坏死和纤维增生呈明显递增趋势。结论DTI的量化指标(ADC、eADC)能够动态观测兔VX2种植型肝癌模型的部分生长特性;为DTI对肝脏病变的临床应用提供一定的理论指导。 更多还原

Abstract: Objective To investigate the feasibility of dynamic magnetic resonance diffusion tensor imaging(DTI) in rabbit models with implanted VX2 hepatic tumor grafts.Methods MRI and DTI images were obtained from 16 rabbit models with implanted VX2 hepatic tumor grafts(14,18,22,and 26 days after tumor implantation,respectively) and 4 normal rabbits.The average diffusion coefficient(ADC) and exponential ADC(eADC) were estimated and compared against pathological findings.Results The ADC values increased after tumor implantation but then decreased in the rabbit models,whereas eADC exhibited a pattern of reverse changes.These changes significantly differed from those in the control group.Coagulation necrosis and fibrous hyperplasia showed obvious increase as found by pathological examination.Conclusion Dynamic MR DTI quantitative analysis of rabbit models of implanted VX2 hepatic tumor can partially describe the growth behaviors of implanted liver cancer.

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