南方医科大学学报

南方医科大学学报 ›› 2006, Vol. 26 ›› Issue (02): 231-233.

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Her-2、EGFR、PS-2、ER在乳腺癌中的表达及其临床意义

徐蕾； 白中红； 许软成； 闫辉； 王方聚； 罗荣城；   

  1. 解放军91医院肿瘤科； 南方医科大学南方医院肿瘤中心 河南焦作454003； 河南焦作454003； 广东广州510515；
  • 出版日期:2006-02-20 发布日期:2006-02-20

Expressions of Her-2, EGFR, PS-2 and ER in breast cancer and their clinical implications

XU Lei, BAI Zhong-hong, XU Ruan-cheng, YAN Hui, WANG Fang-ju, LUO Rong-cheng Department of Oncology, 91 Hospital of PLA, Jiaozuo 454003, China;Oncology Center, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China   

  1. 解放军91医院肿瘤科； 南方医科大学南方医院肿瘤中心 河南焦作454003； 河南焦作454003； 广东广州510515；
  • Online:2006-02-20 Published:2006-02-20

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摘要： 目的探讨人表皮生长因子受体2(Her-2)、表皮生长因子受体(EGFR)、雌激素调节蛋白(PS-2)、雌激素受体(ER) 在乳腺癌中的表达及其临床意义。方法用免疫组织化学方法检测108例乳腺癌患者Her-2、EGFR、PS-2、ER的表达情况,并进行比较。结果 Her-2、EGFR、PS-2、ER表达阳性者分别为40例(37．0％)、44例(40．7％)、62例(57．4％)和58例 (53．7％)。Her-2的表达与EGFR无相关性(P>0．05),与PS-2呈负相关(P<0．05),与ER呈负相关(P<0．05)。Her-2、EGFR、 PS-2、ER表达与乳腺癌的组织学分级相关(P<0．05)。Her-2、EGFR、ER表达与淋巴结转移相关(P<0．05),Her-2、EGFR、 PS-2、ER与乳腺癌的病理学类型、患者年龄及肿瘤大小无关(P>0．05)。结论乳腺癌中Her-2、EGFR表达提示患者预后不良;PS-2、ER表达提示患者预后良好;Her-2、EGFR、PS-2、ER是判断乳腺癌预后的有效指标。 

Abstract: Objective To detect the expressions of human epidermal growth factor receptor 2 (Her-2), epidermal growth factor receptor (EGFR), presenilin 2 (PS-2) and estrogen receptor (ER) in breast cancer and discuss their clinical implications. Methods The expressions of Her-2, EGFR, PS-2 and ER were measured immunohistochemically in 108 patients with breast cancer. Results The positive expression rates of Her-2, EGFR, PS-2 and ER were 37.0%, 40.7%, 57.4% and 53.7% respectively in the breast cancer patients. The expression of Her-2 was not correlated with EGFR, but inversely correlated with PS-2 and ER. The expressions of Her-2 and EGFR, PS-2, ER were correlated with the histological grades (P<0.05), and Her-2, EGFR and ER expressions with lymph node metastasis (P<0.05). The expressions of Her-2, EGFR, PS-2 and ER did not correlate to the pathological types, patient’s age and tumor size (P>0.05). Conclusion Expressions of Her-2 and EGFR often suggests an unfavorable prognosis while expressions of PS-2 and ER suggest a more favorable one. Expressions of Her-2, EGFR, PS-2 and ER are useful prognostic factors in breast cancer patients.

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