南方医科大学学报

南方医科大学学报 ›› 2006, Vol. 26 ›› Issue (02): 227-.

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联合测定血清LDH、TPS、CEA和β2-MG对非霍奇金淋巴瘤的临床意义

陈维； 罗荣城； 樊卫文； 马树东；   

  1. 南方医科大学南方医院肿瘤科； 南方医科大学南方医院肿瘤科 广东广州510515； 广东广州510515；
  • 出版日期:2006-02-20 发布日期:2006-02-20

Clinical value of combined detection of LDH, TPS, CEA and β2-MG in patients with non-Hodgkin’s lymphoma

CHEN Wei, LUO Rong-cheng, FAN Wei-wen, MA Shu-dong Department of Oncology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China   

  1. 南方医科大学南方医院肿瘤科； 南方医科大学南方医院肿瘤科 广东广州510515； 广东广州510515；
  • Online:2006-02-20 Published:2006-02-20

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摘要： 目的探讨在非霍奇金淋巴瘤(NHL)患者中,血清乳酸脱氢酶(LDH)、组织多肽特异性抗原(TPS)、癌胚抗原(CEA) 和β2-微球蛋白(β2-MG)这4项指标测定的临床意义。方法分别采用速率法和酶联免疫吸附法测定59例NHL患者及 40例健康者血清LDH、TPS、CEA和β2-MG值。结果 NHL组血清LDH、TPS、CEA和β2-MG水平高于健康组(P<0．05)。化疗后疗效评价为有效的患者化疗前的血清TPS、β2-MG水平高于化疗后(P<0．05),而化疗后疗效评价为有效的患者化疗前后的血清LDH、CEA水平无显著性差异(P>0．05)。化疗后疗效评价为稳定、进展的患者化疗前后的血清LDH、TPS、 CEA和β2-MG水平也无显著性差异(P<0．05)。结论血清LDH、TPS、CEA和β2-MG水平可作为NHL患者诊断及疗效评估的辅助指标。

Abstract: Objective To study the clinical value of combined detection of 4 tumor markers, namely lactic dehydrogenate (LDH), tissue polypeptide specific antigen (TPS), carcinoembryonic antigen (CEA) and 32-microglobulin (β2-MG) in patients with non-Hodgkin’s lymphoma (NHL). Methods The serum level of LDH was determined with automatic biochemical analyzer and TPS, CEA and β2-MG levels were determined by enzyme-linked immumosorbent assay (ELISA) in 59 patients with NHL and 40 healthy adults. Results The levels of the 4 tumor markers were significantly higher in NHL patients than in the healthy control subjects (P<0.05). After chemotherapy, the serum levels of TPS and β2-MG were significantly lowered in the patients who showed favorable response to the treatment (P<0.05), but the levels of LDH and CEA showed no significant change (P>0.05). The serun levels of LDH, TPS, CEA and P2-MG in the patients in a stable or progressive phase did had no significant changes after chemotherapy (P>0.05). Conclusion Combined detection of LDH, TPS, CEA and β2-MG can be helpful to assist diagnosis of NHL and treatment evaluation.

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