南方医科大学学报 ›› 2006, Vol. 26 ›› Issue (01): 128-129.

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胸腺肽α_1对危重病人气管切开肺部感染的防治作用

黄登鹏;杨鸣;彭卫平;陈小设;陈仲清;   

  1. 连州市人民医院ICU; 南方医科大学南方医院ICU 广东 连州 513400; 广东 连州 513400; 广东 广州 510516;
  • 出版日期:2006-01-20 发布日期:2006-01-20

Prevention and management of lung infections with thymosin α1 in critical patients with tra- cheotomy

HUANG Deng-peng, YANG Ming, PENG Wei-ping, CHEN Xiao-she, CHEN Zhong-qing Intensive Care Unit, People’s Hospital of Lianzhou, Lianzhou 513400, China; Intensive Care Unit, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China   

  1. 连州市人民医院ICU; 南方医科大学南方医院ICU 广东 连州 513400; 广东 连州 513400; 广东 广州 510516;
  • Online:2006-01-20 Published:2006-01-20

摘要: 目的观察胸腺肽α1对气管切开的危重病人肺部感染的治疗作用。方法将被研究的42例病人随机分成2组,即治疗组与对照组,对照组常规治疗加安慰剂,治疗组常规治疗加胸腺肽α1,疗程为7d。结果治疗组肺部感染率、二重感染率、混合感染率明显低于对照组;而且白细胞、C-反应蛋白、肿瘤坏死因子、白细胞介素6下降程度亦比对照组显著, 二者比较,均有显著差异(P<0.01)。结论胸腺肽α1对气管切开的危重病人肺部感染有防治作用,而且可降低白细胞、C- 反应蛋白、肿瘤坏死因子、白细胞介素6等炎症因子水平,提高患者的免疫力,改善患者的预后。 更多还原

Abstract: Objective To evaluate the preventive and therapeutic effect of thymosin α1 on lung infections in critical patients with tracheotomy. Methods Forty-two patients were randomly divided into treatment group and control group to receive daily subcutaneous thymosin injection at 11.6 mg and saline of 2 ml for 7 days, respectively. Results Compared with the control group, the infection rate, white blood cell count, C-reactive protein, tumor necrosis factor-alpha and interleukiu-6 were significantly lower in the treatment group. Conclusions Thymosin α1 can be effective for prevention and treatment of lung infections in critical patients with tracheotomy and may improve the patients’ immunity and prognosis.

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