Abstract: Objective To assess the effect of levonorgestrel-releasing intrauterine system (LNG-IUS) on serum lipids and hepatic function. Methods Blood samples of 35 cases receiving LNG-IUS were collected and determined for serum lipids and hepatic functions. Results Six months after insertions, HDL-C and ApoA were increased significantly, while LDL-C and ApoB decreased significantly. TG and TC levels were decreased at the 6th months and showed significant difference till the end of one year. TG/HDL-C and LDL-C/HDL-C ratios were increased and Apo A/ApoB ratio decreased significantly. The indices of hepatic function varied in the normal ranges, while Glb were decreased significantly after one year. Conclusion LNG-IUS is an effective therapy without obvious adverse effect on lipid metabolism and hepatic function.