南方医科大学学报

南方医科大学学报 ›› 2005, Vol. 25 ›› Issue (10): 1314-1315.

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慢性阻塞性肺疾病和支气管哮喘患者血浆及痰液P物质的测定

张丹, 罗显荣, 叶小群, 董杏芳   

  1. 解放军第四五八医院呼吸科, 广东, 广州, 510600
  • 出版日期:2005-10-20 发布日期:2005-10-20
  • 基金资助:
    收稿日期:2005-5-7。
    作者简介:张丹(1973- ),女,2000年第一军医大学呼吸内科学硕士毕业,主治医师,E-mail:winterpower@163.com

Determination of plasma and sputum substance P content in patients with chronic obstructive pulmonary disease or asthma

ZHANG Dan, LUO Xian-rong, YE Xiao-qun, DONG Xing-fang   

  1. 解放军第四五八医院呼吸科, 广东, 广州, 510600
  • Online:2005-10-20 Published:2005-10-20

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摘要： 目的 检测在慢性阻塞性肺疾病(COPD)和支气管哮喘患者血浆和痰液中P物质(SP)的含量及探讨其作用。方法 收集了26例COPD、20例哮喘和12例健康者的血浆及诱导痰标本,采用放射免疫分析法检测SP的浓度。结果 COPD组血浆及痰液SP浓度分别为(7.9±2.6)和(53.8±12.5)pmol/L,明显高于对照组的(3.6±1.7)和(6.2±2.3)pmol/L,(P<0.01);哮喘组血浆及痰液SP浓度分别为(8.3±3.1)和(46.9±10.2)pmol/L,也明显高于对照组(P<0.01);COPD和哮喘组间SP浓度无显著性差异(P>0.05)。结论 SP可能参与了COPD和哮喘的发病过程。

Abstract: Objective To investigate the role of substance P (SP) in chronic obstructive pulmonary disease (COPD) or asthma. Method Plasma and sputum samples were obtained from 26 COPD patients and 20 asthmatic patients as well as 12 healthy subjects for measurement of SP content. Results Patients with COPD had significantly higher levels of SP in the plasma (7.9±2.6 pmol/L) and sputum (53.8±12.5 pmol/L) than the healthy subjects (3.6±1.7 pmol/L and 6.2±2.3 pmol/L, respectively, P<0.01). The asthmatic patients also had significantly higher SP levels (8.3±3.1 pmol/L and 46.9±10.2 pmol/L, respectively) than the healthy subjects, but there was no significant difference between COPD and asthmatic patients (P>0.05). Conclusion SP may be involved in the airway inflammation process in COPD and asthma.

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