南方医科大学学报

南方医科大学学报 ›› 2005, Vol. 25 ›› Issue (10): 1293-1294,1298.

• • 上一篇    下一篇

TPS、CA-153和CEA联合检测对乳腺癌的诊断价值

郑航, 罗荣城   

  1. 南方医科大学南方医院肿瘤科, 广东, 广州, 510515
  • 出版日期:2005-10-20 发布日期:2005-10-20
  • 基金资助:
    收稿日期:2005-1-10。
    基金项目:国际科技合作课题
    作者简介:郑航(1965- ),男,在读博士研究生,主治医师,电话:020-61641655

Diagnostic value of combined detection of TPS, CA153 and CEA in breast cancer

ZHENG Hang, LUO Rong-cheng   

  1. 南方医科大学南方医院肿瘤科, 广东, 广州, 510515
  • Online:2005-10-20 Published:2005-10-20

PDF

1376

摘要： 目的 探讨组织多肽特异性抗原(TPS)、癌相关糖蛋白抗原(CA153)和癌胚抗原(CEA)三项标志物联合检测对乳腺癌的诊断价值。方法 乳腺癌患者90例,乳腺良性疾病40例,健康对照组30例,应用酶联免疫吸附试验(ELISA)检测TPS、CA153和CEA三项标志物。结果 乳腺癌组三项指标均明显高于健康对照组(P<0.01)。TPS对乳腺癌诊断的敏感性为87.7%,特异性为90.0%;CA153敏感性为55.6%,特异性为93.3%;CEA敏感性为45.8%,特异性为96.7%。三项联合则敏感性为100%。结论 TPS、CA153和CEA对乳腺癌诊断有一定价值,三者联合检测有明显的互补性,可明显提高乳腺癌诊断的敏感性。

Abstract: Objective To study the diagnostic value of combined detection of the 3 tumor markers, namely tissue polypeptide specific antigen (TPS), cancer antigen 153 (CA153), and carcino embryonic antigen (CEA), in patients with breast cancer. Methods The serum levels of TPS, CA153 and CEA were determined by enzyme-linked immumosorbent assay in 90 patients with breast cancer and 30 healthy adults. Results The serum levels of 3 tumor markers in breast cancer patients were significantly higher than those in the control group (P<0.01). The sensitivity of TPS to breast cancer was 87.7% with specificity of 90.0%. The sensitivity and specificity of CA153 to breast cancer was 55.6% and 93.3%, and those of CEA was 45.8% and 96.7%, respectively. The sensitivity of the 3 tumor markers in combination was 100% in breast cancer diagnosis. Conclusion TPS, CA153 and CEA have diagnostic value in breast cancer and possess obvious complementarity, and their combined detection can significantly improve the sensitivity of breast cancer diagnosis.

中图分类号: