南方医科大学学报

南方医科大学学报 ›› 2005, Vol. 25 ›› Issue (09): 1132-1134.

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葛根芩连汤配伍对实验性菌痢药效比较研究

余林中, 伍杰勇, 罗佳波, 陈育尧, 林慧   

  1. 南方医科大学中医系药理药化教研室, 广东, 广州, 510515
  • 出版日期:2005-09-20 发布日期:2005-09-20
  • 基金资助:
    收稿日期:2005-5-6。
    基金项目:国家自然科学基金(39970886);广东省自然科学基金(001070)
    作者简介:余林中(1962- ),男,医学博士,副教授,主要从事中药复方配伍规律与组成原理等基础研究,中药新产品开发研究,电话:020-61648262.

Effects of different compositions of Gegenqinlian decoction on experimental shigellosis in rabbits

YU Lin-Zhong, WU Jie-yong, LUO Jia-Bo, CHEN Yu-rao, LIN Hui   

  1. 南方医科大学中医系药理药化教研室, 广东, 广州, 510515
  • Online:2005-09-20 Published:2005-09-20

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摘要： 目的 观察葛根芩连汤各配伍对菌痢模型药效,探讨其配伍规律。方法 兔盲肠分流术后直接结肠内接种,制作菌痢兔模型。按正交设计方法,观察葛根芩连汤各配伍组合对菌痢模型的肠内容物细菌计数及肠组织内细菌计数,结肠炎指数的影响。结果 葛根芩连汤各配伍对结肠内细菌计数及结肠组织内细菌计数,以黄连、黄芩作用为主,黄连与黄芩相互拮抗,其最佳组合为单味黄连,结肠炎指数为炙甘草。结论 在葛根芩连汤各种配伍对实验性细菌性痢疾的作用上,对细菌的影响,以黄连为优;对病理学损害的改善,以炙甘草为优。

Abstract: Objective To investigate the relations between different compositions of Gegenqinlian decoction and their effects on experimental shigellosis in rabbits to explore the composition protocol of Gegenqinlian decoction. Methods Rabbit models of intestinal invasion induced by Shigella flexneri was established by directly inoculating the bacterium in the colon after cecum bypass operation. The effects of different compositions of Gegenqinlian decoction on the indexes of colitis and the bacterial count of Shigella in the colon content and colon tissue were investigated by orthogonal design. Results According to the bacterial count of Shigella in the colon, Coptis chinensis franch and Scutellaria baicalensis Georgi are the main effective drugs, but they antagonized each other, so that the best combination protocol was Coptis chinensis Franch only. Conclusion Among the components of Gegenqinlian decoction, Coptis chinensis franch has the strongest pharmcological effect against bacteria and Glycyrrhina wralensis fisch is the most effective to ameliorate pathological lesions.

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