南方医科大学学报

南方医科大学学报 ›› 2005, Vol. 25 ›› Issue (08): 1034-1036.

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缺氧诱导因子-1α和血管内皮生长因子在肾细胞癌组织中的表达及意义

邵志强, 郑少斌, 肖耀军, 谭万龙, 陈彤, 齐桓, 姜耀东, 郁兆存, 张辉见   

  1. 南方医科大学南方医院泌尿外科, 广东广州, 510515
  • 出版日期:2005-08-20 发布日期:2005-08-20
  • 基金资助:
    收稿日期:2005-3-9。
    作者简介:邵志强(1972-),男,南方医科大学在读硕士研究生,主治医师,电话:020-61365836,E-mail:shaozq2005@163.com

Expressions of hypoxia inducible factor-1α and vascular endothelial growth factor in human renal cell carcinoma

SHAO Zhi-qiang, ZHENG Shao-bin, XIAO Yao-jun, TAN Wan-long, CHEN Tong, QI Huan, JIANG Yao-dong, YU Zhao-cun, ZHANG Hui-jian   

  1. 南方医科大学南方医院泌尿外科, 广东广州, 510515
  • Online:2005-08-20 Published:2005-08-20

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摘要： 目的 检测缺氧诱导因子-1α(HIF-1α)和血管内皮生长因子(VEGF)在肾细胞癌中的表达及其相互关系。方法 用免疫组织化学SABC法检测42例肾细胞癌组织中HIF-1α及VEGF蛋白的表达。结果 肾细胞癌组织中HIF-1α阳性表达率为57.1%,癌旁及正常组织不表达;肾细胞癌VEGF阳性表达率为61.9%,与癌旁及正常组织(阳性表达率为20%)相比有显著性差异(P<0.05);癌转移患者与无癌转移者HIF-1α、VEGF比较均有显著性差异(P<0.01);HIF-1α与VEGF表达呈正相关(Kappa=0.41,P<0.01)。结论 HIF-1α在肾细胞癌组织中呈高表达,其与VEGF有相关性,有望成为判断肾细胞癌转移和预后等生物学行为的重要参考指标,HIF-1α是VEGF表达的调控因子之一。

Abstract: Objective To explore the expression of hypoxia inducible factor-1α(HIF-1α) and vascular endothelial growth factor (VEGF) in renal cell carcinoma (RCC) and their relationship. Methods The expression of HIF-1αand VEGF was examined in 42 patients with renal cell carcinoma by SABC methods of immunohistochemistry. Results The positivity rate of HIF-1α was 57.1% in the RCC tissues, and there was no expression in the tissue adjacent to the tumor and normal tissues. The positivity rate of VEGF was 61.9% in the tumor tissues, with significant difference from the control tissues (P<0.05). The expression levels of HIF-1α and VEGF were significantly higher in metastatic RCC than in non-metastatic RCC (P<0.01) tissues, and there was a significant correlation between HIF-1α and VEGF expressions (Kappa=0.41, P<0.01). Conclusions HIF-1α is highly expressed in renal cell carcinoma tissues in close correlation with VEGF. HIF-1α and VEGF may serve as important indicators to evaluate the biological behaviors of RCC such as metastasis and prognosis. HIF-1α is an important regulator of VEGF.

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