南方医科大学学报

南方医科大学学报 ›› 2005, Vol. 25 ›› Issue (07): 837-839.

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益元口服液对辐射损伤小鼠辅助防护作用

骆苏芳, 刘国章   

  1. 南方医科大学健康食品研究所, 广东, 广州, 510515
  • 出版日期:2005-07-20 发布日期:2005-07-20
  • 基金资助:
    收稿日期:2005-2-6。
    基金项目:广州市科技攻关项目(2005Z3.E5031)
    作者简介:骆苏芳(1958- ),女,副教授,主要研究方向:心血管药理学及保健食品开发、研制,电话:020-61647781

Assisting protective effect of Yiyuan oral solution on mice from irradiation injury

LUO Su-fang, LIU Guo-zhang   

  1. 南方医科大学健康食品研究所, 广东, 广州, 510515
  • Online:2005-07-20 Published:2005-07-20

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摘要： 目的 探讨益元口服液对小鼠辐射损伤的辅助保护作用。方法 小鼠口服高剂量(10ml/kg·b.w.)、中剂量(3.33ml/kg·b.w.)、低剂量(1.67ml/kg·b.w.)益元口服液30d后接受60Co-γ射线3Gy照射,观察对小鼠一次性全身照射60Co-γ射线3Gy引起的小鼠外周血白细胞下降、骨髓细胞微核率增加及血清溶血素降低等损伤指标的影响。结果 益元口服液高剂量组能明显增加经一次60Co-γ射线全身照射后小鼠的外周血白细胞总数,降低骨髓细胞微核发生率,提高血清溶血素水平。结论 益元口服液对小鼠辐射损伤有辅助保护作用。

Abstract: Objective To study the protective effect of Yiyuan oral solution against radiation injury in mice. Methods Yiyuan oral solution was administered in mice at 10.00,3.33 and 1.67 ml/kg for 30 days.The mice were then exposed to 60Co-γ irra- diation at 3 Gy once and the effect of the irradiation on the WBC,bone marrow polychromatic erythrocytes (PEC) micronuclei and serum hemolysin antibody against sheep red cells. Results and Conclusion Yiyuan oral solution at 10 ml/kg significantly increased WBC counts,decreased bone marrow PEC micronucleus rate and enhanced serum hemolysin antibody in mice,suggesting the protective effect of this preparation against radiation injury.

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