口腔癌及癌前病变中FHIT与cyclinD1/CDK4表达的相关性研究

南方医科大学学报 ›› 2005, Vol. 25 ›› Issue (07): 812-814.

口腔癌及癌前病变中FHIT与cyclinD1/CDK4表达的相关性研究

殷操¹, 沈丽佳², 谢思明², 阮萍², 姚希²

1. 广东省口腔医院, 广东, 广州, 510280;
2. 暨南大学医学院口腔医学系, 广东, 广州, 510632

出版日期:2005-07-20 发布日期:2005-07-20
基金资助:
收稿日期:2005-4-5。
基金项目:广东省科技厅攻关项目(98-11)
作者简介:殷操(1965- ),男,医学硕士,副主任医师,科主任,电话:020-84427024,E-mail:yin9731@hotmail.com

Expressions of FHIT and cyclin D1/CDK4 in oral cancer and oral precancerous lesions

YIN Cao¹, SHEN Li-jia², XIE Si-ming², RUAN Ping², YAO Xi²

1. 广东省口腔医院, 广东, 广州, 510280;
2. 暨南大学医学院口腔医学系, 广东, 广州, 510632

Online:2005-07-20 Published:2005-07-20

摘要/Abstract

摘要： 目的通过检测cyclinD1/CDK4在口腔鳞癌(OSCC)及癌前病变中的表达,并分析它们在口腔癌中的作用及相关关系。方法采用免疫组化SP法检测64例OSCC、39例口腔癌前病变、12例正常口腔粘膜中cyclinD1、CDK4蛋白表达的情况,并比较其相关性。结果 cyclinD1/CDK4在OSCC组中的表达明显高于正常组和癌前病变组(P<0.01)。Spearman等级相关分析表明FHIT与cyclinD1、CDK4之间相关性不明显,而cyclinD1、CDK4之间有正相关关系。结论 FHIT、cyclinD1、CDK4在OSCC的发生和发展过程中起着一定的作用。FHIT可能并不通过影响cyclinD1/CDK4来发挥其功能。

Abstract: Objective To detect the expressions of fragile histidine triad (FHIT) and cyclin D1/CDK4 in oral squamous cell carcinoma (OSCC) and oral precancerous lesions and investigate the relationship between the expressions and the histopatho- logical changes. Methods Immunohistochemical staining by SP methods was utilized to detect the expression of FHIT and cyclin D1/CDK4 in 64 cases of OSCC,39 oral precancerous lesions and 12 normal oral mucosa specimens. Results The rate of the negative or low FHIT expression in OSCC was 17% (11/64),which was remarkably lower than that in normal oral membrane and oral precancerous lesions (P<0.01).Significantly higher levels of cyclin D1/CDK4 expressed in OSCC than in normal oral membrane and precancerous lesions (P<0.01).There was no significant correlation between FHIT and cyclin D1/CDK4,and positive correlation between cyclin D1 and CDK4 was observed. Conclusion FHIT,cyclin D1 and CDK4 may play a role in the pathogenesis of OSCC,and FHIT can down-regulate the expression of cyclin D1.

中图分类号:

R781

殷操¹, 沈丽佳², 谢思明², 阮萍², 姚希². 口腔癌及癌前病变中FHIT与cyclinD1/CDK4表达的相关性研究[J]. 南方医科大学学报, 2005, 25(07): 812-814.

YIN Cao¹, SHEN Li-jia², XIE Si-ming², RUAN Ping², YAO Xi². Expressions of FHIT and cyclin D1/CDK4 in oral cancer and oral precancerous lesions[J]. Journal of Southern Medical University, 2005, 25(07): 812-814.

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