南方医科大学学报

南方医科大学学报 ›› 2005, Vol. 25 ›› Issue (07): 802-804.

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恶性肿瘤患者医院感染120例临床分析

郭杰1, 栾萍1, 李湛全2   

  1. 1. 广州经济技术开发区医院血液内科, 广东, 广州, 510730;
    2. 青海医学院附属医院血液科, 青海, 西宁, 810001
  • 出版日期:2005-07-20 发布日期:2005-07-20
  • 基金资助:
    收稿日期:2004-12-29。
    基金项目:广东省医学科研基金(A2004593)
    作者简介:郭杰(1961- ),男,硕士,副主任医师,电话:020-82087088

Clinical analysis of 120 cases of malignancies with nosocomial infections

GUO Jie1, LUAN Ping1, LI Zhan-quan2   

  1. 1. 广州经济技术开发区医院血液内科, 广东, 广州, 510730;
    2. 青海医学院附属医院血液科, 青海, 西宁, 810001
  • Online:2005-07-20 Published:2005-07-20

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摘要： 目的 探讨恶性肿瘤患者粒细胞缺乏期发生医院感染的特点及防治对策。方法 回顾性分析我院1997年1月~2003年12月收治的120例恶性肿瘤患者化疗后粒细胞缺乏期医院感染发生的特点,分析感染发生的因素及感染种类等以及治疗效果。结果 发生院内感染的恶性肿瘤患者中,急性白血病患者、肺癌为主(70/120)。感染部位以呼吸道感染最多,占78.89%,其次是口腔粘膜、胃肠道、皮肤及腹腔等。感染种类以细菌为主,真菌感染有明显上升趋势。导致感染的病原菌主要为G-菌,对美罗培南、亚胺培南/西司他丁较敏感。结论 恶性肿瘤患者院内感染机率较高,作好基础护理,肠道消毒及粒细胞刺激因子等,合理使用抗生素,警惕真菌感染等是预防和治疗恶性肿瘤患者医院感染的重要措施。

Abstract: Objective To explore the clinical features and treatment of nosocomial infections in patients with malignancies in the period of agranulocytosis following chemotherapy. Methods The clinical features of hospital-acquired infections were reviewed and analyzed in 120 patients with malignancies in state of agranulocytosis after chemotherapy.The infection-related factors,classification of the pathogens and therapeutic effect were also analyzed. Results The hospital-acquired infections involved mostly patients with acute leukemia and lung cancer (70/120),occurring at the site of the respiratory tract (78.89%),oral mucosa,gastrointestinal tract,skin and abdominal cavity,etc.The pathogens responsible for the infection are mainly bacteria,with increased incidence of mycotic infections.The pathogenic bacteria causing the infections were predominately G-bacterium,which were sensitive to meropenem and imipenem/cilastatin. Conclusion Patients with malignancies are at high risk of hospital-acquired infection.Good basic nursing care,intestinal tract disinfection,application of granulocyte-stimulating factors,adequate use of antibiotics and constant vigilance of mycotic infection are the key measures to prevent and treat these nosocomial infections.

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