南方医科大学学报

南方医科大学学报 ›› 2005, Vol. 25 ›› Issue (06): 723-725.

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血清S100蛋白与星形细胞瘤放射性脑损伤的关系

宋维舒, 郭立兵, 黄志勇, 李俊杰, 吴军   

  1. 广东省第二人民医院/南方医科大学附属南华医院肿瘤科, 广东, 广州, 510317
  • 出版日期:2005-06-20 发布日期:2005-06-20
  • 基金资助:
    收稿日期:2005-1-25。
    作者简介:宋维舒(1962- ),男,医学硕士,副主任医师,电话:020-89168093

Serum S100 protein and radiation-induced brain injury in astrocytoma patients

SONG Wei-shu, GUO Li-bing, HONG Zhi-yong, LI Jun-jie, WU Jun   

  1. 广东省第二人民医院/南方医科大学附属南华医院肿瘤科, 广东, 广州, 510317
  • Online:2005-06-20 Published:2005-06-20

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摘要： 目的 研究血清S100蛋白在诊断星形细胞瘤放射性脑损伤中的作用。方法 采用酶联免疫吸附试验检测86例星形细胞瘤术后患者放射治疗前后血清S100蛋白水平。结果 放射治疗前、治疗疗程中期及治疗疗程结束后血清S100蛋白阳性率分别为0、9.3%(8/86)和19.8%(17/86),治疗前后及治疗组间比较血清S100蛋白阳性率有显著性差异(P<0.05)。结论 星形细胞瘤放射性脑损伤可导致血清S100蛋白水平升高且与星形细胞瘤治疗疗程和剂量相关,检测血清S100蛋白可作为星形细胞瘤放射性脑损伤诊断较早期指标。

Abstract: Objective To study the value of serum S100 protein in the diagnosis of radiation-induced brain injury in astrocytoma patients. Methods Serum S100 protein levels were detected by enzyme-linked immunosorbent assay in 86 astrocytoma patients in the course of radiotherapy. Results The positivity rates of serum S100 protein before, in the middle of and after radiotherapy were 0, 9.3% (8/86) and 19.8% (17/86), respectively, showing significant differences (P<0.05) between these time points for measurement. Conclusion High levels of serum S100 protein are associated with radiation-induced brain injury in astrocytoma patients and may serve as the marker for early diagnosis of the injury.

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