南方医科大学学报

南方医科大学学报 ›› 2005, Vol. 25 ›› Issue (05): 580-581.

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氯沙坦对犬缺血再灌注心肌损伤的保护作用

杨云1, 霍志成1, 彭健2, 贾满盈2, 黄铮2, 王智明1, 陈玉兰1   

  1. 1. 东莞市太平人民医院心内科, 广东, 东莞, 523900;
    2. 南方医科大学南方医院心内科, 广东, 广州, 510515
  • 出版日期:2005-05-20 发布日期:2005-05-20
  • 基金资助:
    收稿日期:2004-10-26。
    作者简介:杨云(1964- ),男,1988年毕业于湖南医科大学,现为南方医科大学在读硕士研究生,副主任医师,电话:0769-5117588-223

Protective effects of losartan against myocardial ischemic reperfusion in intact canine

YANG Yun1, HUO Zhi-cheng1, PENG Jian2, JIA Man-ying2, HUANG Zheng2, WANG Zhi-ming1, CHEN Yu-lan1   

  1. 1. 东莞市太平人民医院心内科, 广东, 东莞, 523900;
    2. 南方医科大学南方医院心内科, 广东, 广州, 510515
  • Online:2005-05-20 Published:2005-05-20

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摘要： 目的 探讨氯沙坦对犬在体心肌缺血再灌注时心肌损伤的保护作用.方法 16只健康家犬,分为组:(1)对照组(n=8),阻断左前降支主干30 min后恢复前降支血流30 min.应用单相动作电位记录技术,同步记录犬在体心肌再灌注时单相动作电位及体表心电图;()氯沙坦组(n=8):氯沙坦5 mg/(kg·d)经胃管灌入,持续周后开胸,缺血再灌注方法及观察指标同对照组.结果 再灌注30 min内,对照组8只犬中有5只出现了早期后除极(EAD)和再灌注室性心律失常,再灌注心律失常发生率为6.5%;氯沙坦组3只犬出现EAD和再灌注室性心律失常(37.5%,P<0.05),氯沙坦组EAD和心律失常发生率较对照组明显减小(P<0.01).结论 氯沙坦可抑制再灌注时EAD的发生,可能因此而减少再灌注心律失常的发生.

Abstract: Objective To evaluate the protective effect of losartan, an angiotensin II type 1 (AT1) receptor antagonist, against myocardial ischemic reperfusion in intact canine.Methods Sixteen dogs were divided into model group(n=8) with left anterior descending coronary artery occlusion for 30 min followed by reperfusion for 30 min and losartan group (n=8) with 5 mg/(kg·d) intragastric losartan administration for 2 weeks before the ischemic-reperfusion model establishment. Monophasic action potential recording technique was employed to observe the incidence of early after depolarization (EAD) and reperfusion arrhythmias.Results In the model group, 5 dogs (62.5%) developed EAD and reperfusion arrhythmia while 3 (37.5%) developed the symptoms in losartan group, showing significant difference between the two groups (P<0.05). No ventricular tachycardia or ventricular fibrillation was observed in losartan group (P<0.01).Conclusion Losartan can suppress the occurrence of EAD during reperfusion following myocardial ischemia to reduce the incidence of reperfusion arrhythmias, suggesting its protective effect against myocardial ischemic injury.

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