南方医科大学学报

南方医科大学学报 ›› 2005, Vol. 25 ›› Issue (05): 550-551.

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定量测定血清心肌肌钙蛋白I、肌红蛋白在急性心肌梗死诊治中的应用

肖洪广, 黄泽红, 刘汉欣, 林勇平   

  1. 广州医学院第一临床学院检验系, 广东, 广州, 510120
  • 出版日期:2005-05-20 发布日期:2005-05-20
  • 基金资助:
    收稿日期:2004-11-2。
    基金项目:广州市科技局应用基础研究项目(2004J1C0211)
    作者简介:肖洪广(1961- ),男,硕士,副主任技师,电话:020-83337750-6028,E-mail:xiaohongguang610904@yahoo.com.cn

Quantitative analysis of serum troponin I and myoglobin in patients with acute myocardial infarction

XIAO Hong-guang, HUANG Ze-hong, LIU Han-Xin, LIN Yong-ping   

  1. 广州医学院第一临床学院检验系, 广东, 广州, 510120
  • Online:2005-05-20 Published:2005-05-20

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摘要： 目的 探讨心肌肌钙蛋白Ⅰ(cTnI)、肌红蛋白(Mb)两种生化指标在急性心肌梗死诊治中的应用价值.方法 对胸痛发作后～4 h的50例急性心肌梗死患者,定量检测血清cTnI、Mb、肌酸激酶(CK)和肌酸激酶同功酶(CK-MB)浓度,并对结果进行统计分析.结果 急性心肌梗死患者Mbc、TnI、CK、CK-MB明显升高;峰值时间:Mb,(8±.)h;CK-MB,(18.1±3.)h;CK,(19.4±4.1)h;cTnI,(18.6±.9)h.病情恶化时各项指标持续上升,病情好转时降至正常范围.对照组的cTnI、Mb、CK和CK-MB4项指标均正常.结论 cTnI是诊断急性心肌梗死较理想的指标,同时Mb可对急性心肌梗死的早期诊断提供一种快速、可靠的生化指标,具有临床应用价值.

Abstract: Objective To investigate the clinical implications of cardiac troponin I (cTnI), myoglobin (Mb), creatine kinase (CK) and creatine kinase isoenzyme (CK-MB) in patients with acute myocardial infarction (AMI).Methods The serum concentrations of cTnI and Mb were determined in 50 patients with AMI 2 to 4 h after chest pain onset and compared with those measured in 50 age-matched healthy subjects.Results The serum levels of cTnI, CK-MB and CK in patients with AMI were significantly higher than those in the control group. Mb levels in AMI group were above the normal range. Mb, CK-MB, CK and cTnI reached the peak levels at 8±2.2, 18.1±3.2, 19.4±4.1 and 18.6±2.9 h after the onset, respectively, and their levels increased with the aggravation of AMI and were reduced to the normal levels with the amelioration of the disease. All the 4 indices were normal in the control group.Conclusion cTnI and Mb are reliable biochemical markers for early diagnosis of AMI and the changes in their serum levels have clinical significance in diagnoses and prognostic judgment of AMI.

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