实验性脑出血血肿周围组织血脑屏障葡萄糖转运蛋白的表达

南方医科大学学报 ›› 2005, Vol. 25 ›› Issue (03): 339-341.

实验性脑出血血肿周围组织血脑屏障葡萄糖转运蛋白的表达

李中秋, 陆兵勋, 吕田明

南方医科大学南方医院神经内科, 广东, 广州, 510515

出版日期:2005-03-20 发布日期:2005-03-20
基金资助:
收稿日期:2004-9-25。
作者简介:李中秋(1968- ),男,在读博士研究生,主治医师,研究方向是脑血管病的诊断和治疗,电话:020-80919161,E-mail:middleautumn@hotmail.com

Expression of glucose transporter 1 in the blood-brain barrier around hematoma in rats with cerebral hemorrhage

LI Zhong-qiu, LU Bing-xun, LÜ Tian-ming

南方医科大学南方医院神经内科, 广东, 广州, 510515

Online:2005-03-20 Published:2005-03-20

摘要/Abstract

摘要： 目的观察实验性脑出血血肿周围组织血脑屏障葡萄糖转运蛋白1(GLUT₁ )的表达。方法建立脑出血大鼠模型,使用免疫组化检测脑出血血肿周围组织血脑屏障GLUT₁ 的表达。结果脑出血后12h,GLUT₁ 表达增强,24h达到高峰,48h后表达减少。结论脑出血早期,血肿周围血脑屏障GLUT₁ 表达增多,有助于恢复脑的能量代谢。

Abstract: Objective To observe the expression of glucose transporter 1 (GLUT₁ ) in the blood-brain barrier around the hematoma in rats with cerebral hemorrhage.Method Brain tissue around the hematoma in rats with cerebral hemorrhage was prepared for GLUT₁ detection by immunohistochemistry.Result The expression of GLUT₁ upregulated within 48h after cerebral hemorrhage and downregulated afterwards.Conclusion Protective reaction of the blood-brain barrier can be initiated to ensure glucose supply to the neurons against the injury by cerebral hemorrhage.

中图分类号:

R743.43

李中秋, 陆兵勋, 吕田明. 实验性脑出血血肿周围组织血脑屏障葡萄糖转运蛋白的表达[J]. 南方医科大学学报, 2005, 25(03): 339-341.

LI Zhong-qiu, LU Bing-xun, LÜ Tian-ming. Expression of glucose transporter 1 in the blood-brain barrier around hematoma in rats with cerebral hemorrhage[J]. Journal of Southern Medical University, 2005, 25(03): 339-341.

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