腹部多器官联合移植的围手术期处理

南方医科大学学报 ›› 2005, Vol. 25 ›› Issue (02): 165-167.

腹部多器官联合移植的围手术期处理

于立新, 叶俊生, 邓文锋, 徐健, 付绍杰, 叶桂荣, 杜传福, 王亦斌, 刘小友, 苗芸

南方医科大学南方医院器官移植中心, 广东, 广州, 510515

出版日期:2005-02-20 发布日期:2005-02-20
基金资助:
收稿日期:2005-1-17。
基金项目:全军医学科学技术研究“十五”计划基金重点课题项目(01Z049);广东省科技攻关项目(2KM05101S)
作者简介:于立新(1950- ),男,主任医师、教授,电话:020-61641720,E-mail:yejs@fimmu.com

Perioperative management of multiorgan transplantation

YU Li-xin, YE Jun-sheng, DENG Wen-feng, XU Jian, FU Shao-jie, YE Gui-rong, DU Chuan-fu, WANG Yi-bin, LIU Xiao-you, MIAO Yun

南方医科大学南方医院器官移植中心, 广东, 广州, 510515

Online:2005-02-20 Published:2005-02-20

摘要/Abstract

摘要： 目的总结腹部多器官联合移植的围手术期处理经验。方法我院自2001年10月至2005年1月共施行19例腹部多器官联合移植术,其中胰肾联合移植6例、肝肾联合移植12例、肝胰联合移植1例;分析手术方法、免疫抑制剂的使用和术后并发症处理的方法。结果 19例患者手术均获成功,术后发生FK506中毒1例(5.3%),发生急性排斥反应3例(15.8%),消化道出血发生2例(10.5%),腹腔出血1例(5.3%),肺部感染1例(5.3%),经相应治疗后好转。结论腹部多器官联合移植成功的关键是作好供体选择、保证供器官质量、选择适当手术方式、术后合理应用免疫抑制剂以及有效防治术后并发症。

Abstract: Objective To summarize the experience with perioperative management of multiorgan transplantation. Methods From October 2001 to January 2005, 19 patients received multiorgan transplantation in Nanfang Hospital, including 6 with simultaneous kidney-pancreas transplantation(SKPT), 12 with combined liver-kidney transplantation(CLKT), and 1 with simultaneous liver-pancreas transplantation(SLPT). The surgical techniques, application of immunosuppressants, and complication management were reviewed. Results All transplantation procedures were performed successfully. The transplantation-related complications included tacrolimus-induced renal toxicosis in 1(5.3%) case, acute graft rejection in 3(15.8%) cases, intestinal hemorrhage in 2(10.5%) cases, intra-abdominal hemorrhage in 1(5.3%) case, and lung infection in 1(5.3%) case, all of which were cured after proper treatment. Conclusions Donor selection, good quality of the donor organ, proper surgical approaches, adequate use of the-mmunosuppressants, and prevention of complications are essential to the success of multiorgan transplantation.

中图分类号:

R617

于立新, 叶俊生, 邓文锋, 徐健, 付绍杰, 叶桂荣, 杜传福, 王亦斌, 刘小友, 苗芸. 腹部多器官联合移植的围手术期处理[J]. 南方医科大学学报, 2005, 25(02): 165-167.

YU Li-xin, YE Jun-sheng, DENG Wen-feng, XU Jian, FU Shao-jie, YE Gui-rong, DU Chuan-fu, WANG Yi-bin, LIU Xiao-you, MIAO Yun. Perioperative management of multiorgan transplantation[J]. Journal of Southern Medical University, 2005, 25(02): 165-167.

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