南方医科大学学报

南方医科大学学报 ›› 2005, Vol. 25 ›› Issue (01): 119-120.

• • 上一篇    

高效液相色谱法测定水母雪莲中东莨菪内酯、伞形花内酯的含量

苏薇薇1, 赵洁2, 林敬明3   

  1. 1. 南方医科大学研究生大队, 广东广州510515;
    2. 南方医科大学南方医院药材科, 广东广州510515;
    3. 南方医科大学珠江医院药材科, 广东广州510282
  • 出版日期:2005-01-20 发布日期:2005-01-20
  • 基金资助:
    收稿日期:2004-2-16。
    作者简介:苏薇薇(1959- ),女,博士研究生,电话:020-84110808

Determination of scopoletin and umbelliferone contents in Saussurea medusa Maxim by high-performance liquid chromatography

SU Wei-wei1, ZHAO Jie2, LIN Jing-ming3   

  1. 1. 南方医科大学研究生大队, 广东广州510515;
    2. 南方医科大学南方医院药材科, 广东广州510515;
    3. 南方医科大学珠江医院药材科, 广东广州510282
  • Online:2005-01-20 Published:2005-01-20

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摘要： 用高效液相色谱法测定水母雪莲中东莨菪内酯、伞形花内酯的含量。色谱柱采用Merck Lichrospher100RP-18e(250mm×4.0mm,5μm);流动相采用甲醇-四氢呋喃水溶液;检测波长为346nm。东莨菪内酯平均回收率为100.07%,RSD为1.42%;伞形花内酯平均回收率为99.41%,RSD为2.06%。本法简单、快速、准确,可用于水母雪莲的质量控制。

Abstract: Objective To investigate the therapeutic effect of photodynamic therapy (PDT) combined with interstitial chemo-therapy on gliomas after microsurgery. Methods Twenty-eight patients with glioma received microsurgery for glioma resection as much as possible, during which PDT was carried out and an Ommaya bursa implanted into the cavity left by the resected tumor. PDT was performed again 24 h after the operation and carmustine injected into the Ommaya bursa for interstitial chemotherapy at the different time after the operation. The follow-up study lasted for 2 years. Results Two of the 28 patients had relapse of glioma within 1 year after the operation, with the 1-year survival rate of 89.3% (25/28) and 2-year survival rate of 65.7% (17/28). Conclusions PDT combined with interstitial chemotherapy following microsurgery provides a safe and effective treatment of glioma, which can inhibit glioma growth, decrease the recurrence rate, prolong the patients’ survival and improve their quality of live.

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