光动力学疗法与间质内化疗联合治疗脑胶质瘤的临床研究

南方医科大学学报 ›› 2005, Vol. 25 ›› Issue (01): 116-118.

光动力学疗法与间质内化疗联合治疗脑胶质瘤的临床研究

陈利锋, 柯以铨, 杨志林, 王松青, 徐如祥

南方医科大学珠江医院神经外科, 广东广州510282

出版日期:2005-01-20 发布日期:2005-01-20
基金资助:
收稿日期:2004-11-3。
作者简介:陈利锋(1976- ),男,在读硕士研究生,电话:020-61643263,E-mail:supertank@126.com
通讯作者:柯以铨(1963- ),男,博士,教授,主任医师,电话:020-61643266,E-mail:keyiquan@hotmail.com

Effect of photodynamic therapy combined with interstitial chemotherapy for gliomas

CHEN Li-feng, KE Yi-quan, YANG Zhi-lin, WANG Song-qing, XU Ru-xiang

南方医科大学珠江医院神经外科, 广东广州510282

Online:2005-01-20 Published:2005-01-20

摘要/Abstract

摘要： 目的探讨显微手术后联合光动力学疗法(PDT)与局部间质化疗对脑胶质瘤的疗效。方法 28例脑胶质瘤患者术中尽可能多地切除肿瘤后行PDT首次照射,并在残瘤腔内埋置Ommaya囊,24h后行PDT复照。通过Ommaya囊向瘤腔内注射卡氮介行局部间质化疗。随访2年。结果 1年复发2例(7.1%),1年生存25例(89.3%),2年生存17例(65.7%)。结论显微手术后联合PDT与局部间质化疗治疗脑胶质瘤能有效抑制肿瘤生长,控制复发,延长生存期,改善生存质量,是一种安全有效的综合治疗脑胶质瘤的方法。

Abstract: Objective To investigate the therapeutic effect of photodynamic therapy (PDT) combined with interstitial chemo-therapy on gliomas after microsurgery. Methods Twenty-eight patients with glioma received microsurgery for glioma resection as much as possible, during which PDT was carried out and an Ommaya bursa implanted into the cavity left by the resected tumor. PDT was performed again 24 h after the operation and carmustine injected into the Ommaya bursa for interstitial chemotherapy at the different time after the operation. The follow-up study lasted for 2 years. Results Two of the 28 patients had relapse of glioma within 1 year after the operation, with the 1-year survival rate of 89.3% (25/28) and 2-year survival rate of 65.7% (17/28). Conclusions PDT combined with interstitial chemotherapy following microsurgery provides a safe and effective treatment of glioma, which can inhibit glioma growth, decrease the recurrence rate, prolong the patients’ survival and improve their quality of live.

中图分类号:

R739.41

陈利锋, 柯以铨, 杨志林, 王松青, 徐如祥. 光动力学疗法与间质内化疗联合治疗脑胶质瘤的临床研究[J]. 南方医科大学学报, 2005, 25(01): 116-118.

CHEN Li-feng, KE Yi-quan, YANG Zhi-lin, WANG Song-qing, XU Ru-xiang. Effect of photodynamic therapy combined with interstitial chemotherapy for gliomas[J]. Journal of Southern Medical University, 2005, 25(01): 116-118.

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