南方医科大学学报

南方医科大学学报 ›› 2004, Vol. 24 ›› Issue (12): 1422-1424.

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湿热环境对辐射损伤动物骨髓和脾脏的影响

郑莉, 周美娟, 丁振华   

  1. 南方医科大学热卫系放射医学教研室, 广东, 广州, 510515
  • 出版日期:2004-12-20 发布日期:2004-12-20
  • 基金资助:
    收稿日期:2004-3-6。
    作者简介:郑莉(1975- ),女,军事预防医学放射医学专业在读硕士研究生,电话:020-61640114-89131,E-mail:fyzhengli@21cn.com.
    通讯作者:丁振华,E-mail:dingzh@fimmu.com

Effect of hot and humid environment on bone marrow and spleen of mice exposed to γ irradiation

ZHENG Li, ZHOU Mei-juan, DING Zhen-hua   

  1. 南方医科大学热卫系放射医学教研室, 广东, 广州, 510515
  • Online:2004-12-20 Published:2004-12-20

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摘要： 目的 研究湿热环境对辐射损伤动物骨髓和脾脏的影响。方法 将实验动物分为室温组和湿热环境组,两组小鼠首先分别给予6.5Gyγ射线一次全身均匀照射,然后室温组立即置于室温环境中,湿热环境组则先接受湿热环境作用1h,再置于室温环境中。照后1、3、5、9、15d,分别取两组小鼠的骨髓和脾脏,获取骨髓有核细胞(BMC)数、骨髓细胞DNA、脾/体质量比实验指标。结果 湿热环境作用组小鼠和室温组小鼠相比,BMC、骨髓细胞DNA及脾/体质量比指标下降。结论 湿热环境加重辐射损伤动物骨髓和脾脏的损伤。

Abstract: Objective To study the effect of hot and humid environment (HHE) on the bone marrow and spleen in mouse exposed to γ irradiation. Methods After exposure to γ irradiation at the dosage of 6.5 Gy, the mice were subjected to treatment in HHE for 1 h or at room temperature (RT) respectively. After exposure to HHE, the mice in HHE group were kept at RT. The bone marrow and spleen of the mice in both RT and HHE groups were examined at 1, 3, 5, 9 and 15 days after irradiation for bone marrow cellularity, DNA content in the bone marrow cells, and spleen/body weight ratio. Results Compared with the RT group, mice in the HEE group showed aggravation of decreases in bone marrow cells, DNA content and spleen/body weight ratio. Conclusions HHE aggravates radiation injury of the bone marrow and spleen in mice.

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