内皮素和降钙素基因相关肽在实验性孕兔急性肺栓塞体内的表达

南方医科大学学报 ›› 2004, Vol. 24 ›› Issue (12): 1382-1385.

内皮素和降钙素基因相关肽在实验性孕兔急性肺栓塞体内的表达

钟梅¹, 崔宝奎², 余艳红¹, 黄莉萍¹, 刘宝瑛¹, 宋天蓉¹

1. 南方医科大学南方医院妇产科, 广东, 广州, 510515;
2. 解放军537医院妇产科, 陕西, 宝鸡, 721000

出版日期:2004-12-20 发布日期:2004-12-20
基金资助:
收稿日期:2004-5-19。
基金项目:广东省医学科研基金(A2003456);
作者简介:钟梅(1960- ),女,毕业于中山医科大学,南方医科大学在读博士,教授,电话:020-61641907

Changes in serum endothelin and in pregnant rabbits with pulmonary embolism pulmonary embolism

ZHONG Mei¹, CUI Bao-kui², YU Yan-hong¹, HUANG Li-ping¹, Liu Bao-ying¹, SONG Tian-rong¹

1. 南方医科大学南方医院妇产科, 广东, 广州, 510515;
2. 解放军537医院妇产科, 陕西, 宝鸡, 721000

Online:2004-12-20 Published:2004-12-20

摘要/Abstract

摘要： 目的探讨内皮素和降钙素基因相关肽在实验性孕兔肺栓塞模型血清中含量的变化。方法实验组17只孕兔采用自体血凝块经股静脉注入右心房内,造成肺栓塞模型,对照组10只孕兔注入生理盐水。分别于注栓前、注栓后0、2、4、8h测定血清中内皮素和降钙素基因相关肽含量。结果实验组全部有肺栓塞的病理改变,发生率为100%,实验组的血120浆中内皮素于栓塞后即刻增高至栓塞后6h,降钙素基因相关肽注栓后即刻降低,注栓后4h增高并持续至栓塞后8h,与对照组比较,有显著性差异(P<0.05)。结论内皮素和降钙素基因相关肽在实验性孕兔肺栓塞时血清含量会发生显著变化。

Abstract: Objective To study change of serum endothelin (ET) and in serum endothelin and in pregnant rabbit with acute pulmonary embolism. Methods In 17 pregnant rabbits, autologous blood clots were administered into the right atrium via the femoral vein to establish the animal models of acute pulmonary embolism, and another 10 pregnant rabbits received injection with saline to serve as the control group. Serum levels of ET and CGRP were measured before, 0, 2, 4, 6 and 8 h after the injectsion. Results Acute pulmonary embolism was induced in all the rabbits receiving the injection of autologous blood clots with a success rate of 100%. In these rabbit models of pulmonary embolism, serum ET increased 0 h after the embolism and kept rising till 6 h, whereas CGRP level underwent immediate decrease after the embolism followed then by increase during the period from 4 to 8 h, showing significant difference from the levels of the control group. Conclusion Significant difference in serum ET and CGRP levels occur in the event of acute pulmonary embolism in pregnant rabbits.

中图分类号:

Q471
R965.1

钟梅¹, 崔宝奎², 余艳红¹, 黄莉萍¹, 刘宝瑛¹, 宋天蓉¹. 内皮素和降钙素基因相关肽在实验性孕兔急性肺栓塞体内的表达[J]. 南方医科大学学报, 2004, 24(12): 1382-1385.

ZHONG Mei¹, CUI Bao-kui², YU Yan-hong¹, HUANG Li-ping¹, Liu Bao-ying¹, SONG Tian-rong¹. Changes in serum endothelin and in pregnant rabbits with pulmonary embolism pulmonary embolism[J]. Journal of Southern Medical University, 2004, 24(12): 1382-1385.

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