南方医科大学学报

南方医科大学学报 ›› 2004, Vol. 24 ›› Issue (11): 1326-1327.

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芬太尼对罗哌卡因妇科术后硬膜外腔镇痛半数有效浓度的影响

徐建设1, 杨吉武2, 古妙宁1, 陈晔明1   

  1. 1. 南方医科大学南方医院麻醉科, 广东, 广州, 510515;
    2. 广州空军总医院麻醉科, 广东, 广州, 510602
  • 出版日期:2004-11-20 发布日期:2004-11-20
  • 基金资助:
    收稿日期:2004-3-27。
    作者简介:徐建设(1966- ),男,硕士,E-mail:mzkgmn@263.net

Effects of fentanyl on EC50 of ropivacaine for postoperative epidural analgesia after gynecological surgery

XU Jian-she1, YANG Ji-wu2, GU Miao-ning1, CHEN Ye-ming1   

  1. 1. 南方医科大学南方医院麻醉科, 广东, 广州, 510515;
    2. 广州空军总医院麻醉科, 广东, 广州, 510602
  • Online:2004-11-20 Published:2004-11-20

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摘要： 目的 测定罗哌卡因用于妇科术后硬膜外腔镇痛的半数有效浓度(EC50)并观察芬太尼对罗哌卡因EC50的影响。方法 选择ASA(美国麻醉医师协会) 分级Ⅰ~Ⅱ级在硬膜外腔阻滞麻醉下行择期妇科手术的病人65例,随机分为罗哌卡因(R组)和罗哌卡+因芬太尼(RF组)组,分别用罗哌卡因以及罗哌卡因+芬太尼20 ml(2 μg/ml)进行术后硬膜外腔镇痛。罗哌卡因的给药浓度按序贯实验法进行调整。以视觉模拟评分法(VAS)评估镇痛效果,按Dixon法计算罗哌卡因的EC50值。结果 R组的罗哌卡因EC50为0.098%;RF组的罗哌卡因EC50为0.069%,RF组较R组显著降低(P<0.01)。结论 罗哌卡因妇科术后硬膜外腔镇痛的EC50为0.098%。芬太尼可降低罗哌卡因术后镇痛的EC50。

Abstract: Objective To determine the effect of fentanyl on 50% effective concentration (EC50) of ropivacaine for postoperative epidural analgesia following gynecological surgery.Methods Sixty-five patients (ASA class I to II) scheduled for elective gynecological surgery were randomly divided into two groups to receive 20 ml ropivacaine (group R, n=33) or ropivacaine combined fentanyl (group RF, n=32) for postoperative epidural analgesia. The concentration of ropivacaine was adjusted according to double-blinded up-down sequential allocation. The efficacy was assessed using visual analog scores (VAS) and EC50 calculated using method of Dixon.Results The EC50 of ropivacaine was 0.098% in group R and 0.069% in group RF, showing significant difference (P<0.01).Conclusion EC50 of ropivacaine for postoperative epidural analgesia determined by up-down sequential allocation is 0.098%, which can be decreased by the use of fentanyl.

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