南方医科大学学报

南方医科大学学报 ›› 2004, Vol. 24 ›› Issue (11): 1316-1318.

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年龄与正常脑白质平均表观扩散系数的相关性

赵修义, 张雪林, 王劲, 陈斌, 苍鹏, 昌仁民   

  1. 南方医科大学南方医院影像中心, 广东, 广州, 510515
  • 出版日期:2004-11-20 发布日期:2004-11-20
  • 基金资助:
    收稿日期:2004-2-14。
    作者简介:赵修义(1963- ),男,2003年毕业于第一军医大学,副主任医师,医学博士.现工作单位:济南军区总医院放射科,电话:0531-2166984

Correlation between age and average apparent diffusion coefficient in normal-appearing cerebral white matter

ZHAO Xiu-yi, ZHANG Xue-lin, WANG Jin, CHEN Bin, CANG Peng, CHANG Ren-min   

  1. 南方医科大学南方医院影像中心, 广东, 广州, 510515
  • Online:2004-11-20 Published:2004-11-20

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摘要： 目的 定量研究不同年龄段正常脑白质磁共振扩散加权成像平均表观扩散系数(ADCav)值,分析年龄因素对正常脑白质ADCav值的影响。方法 选取50例具有正常MRI表现的患者作为研究对象,按其年龄段分为4组:第1组(16~30岁,n=13),第2组(31~45岁,n=12),第3组(46~60,n=14)及第4组(>60岁,n=11);所有病人均行常规MR及扩散加权成像检查,扩散加权成像序列采用扩散梯度加在3个正交方向上的扩散追踪加权成像(trace-weighted diffu-sion imaging),定量测量白质区ADCav值,比较分析不同年龄段ADCav值特性。结果 脑白质ADCav值为(0.71±0.08)×10-3 mm2/s;不同年龄段4组ADCav值分别为:(0.69±0.06)×10-3 mm2/s,(0.71±0.07)×10-3 mm2/s,(0.71±0.09)×10-3 mm2/s,(0.73±0.10)×10-3 mm2/s;第1组ADC值与第4组ADC值间存在显著性差异(P=0.014);年龄大于60岁与年龄小于或等于60岁两组ADCav值分别为(0.73±0.10)×10-3 mm2/s、(0.70±0.07)×10-3 mm2/s,两组比较存在显著性差异(P=0.026)。结论 随年龄的增长,正常脑白质ADCav值呈现微弱增长趋势,其原因可能为正常的年龄变化所致的脑内超微结构的改变。

Abstract: Objective To quantitatively study the effect of ages on the average apparent diffusion coefficient (ADCav) of normal-appearing white matter.Methods Fifty patients with normal-appearing white matter were divided into four age groups, namely 16-30 years, (n=13), 31-45 years (n=12), 46-60 years (n=14) and >60 years (n=11). All the subjects were examined with conventional and trace-weighted diffusion imaging in three orthogonal directions. The ADCav of the white matter was measured and compared between various age groups.Results In the white matter, the ADCav of all the patients was (0.71±0.08)×10-3 mm2/s; the ADCav of the white matter in the first to fourth age groups were (0.69±0.06)×10-3 mm2/s, (0.71±0.07)×10-3 mm2/s, (0.71±0.09)×10-3 mm2/s, and (0.73±0.10)×10-3 mm2/s respectively. ADCav of patients between 16-30 years was significantly different from that of patients over 60 years of age (P=0.014). Patients older than 60 years had an ADCav of the white matter significantly higher than the value of (0.70±0.07)×10-3 mm2/s in the total patients younger than 60 years (P=0.026).Conclusion Water diffusibility shows a slight increase in human white matter with aging, possibly due to mild ultrastructural changes associated with aging.

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