南方医科大学学报

南方医科大学学报 ›› 2004, Vol. 24 ›› Issue (11): 1292-1294.

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含碘食物对Graves病患者甲状腺131I与99mTc摄取的不同影响

何国荣, 欧阳伟, 刘金华, 刘伟英   

  1. 第一军医大学珠江医院核医学科, 广东, 广州, 510282
  • 出版日期:2004-11-20 发布日期:2004-11-20
  • 基金资助:
    收稿日期:2003-4-19。
    作者简介:何国荣(1965- ),男,1998年毕业于中国协和医科大学,医学博士,主治医师,讲师.电话:020-61643473,E-mail:heguorong@vip.sina.com

Effects of iodine-containing food on 99mTc and 131I uptake in patients with Graves’ disease

HE Guo-rong, OUYANG Wei, LIU Jin-hua, LIU Wei-ying   

  1. 第一军医大学珠江医院核医学科, 广东, 广州, 510282
  • Online:2004-11-20 Published:2004-11-20

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摘要： 目的 探讨含碘食物对Graves病患者摄取99mTc与131I的影响。方法 选择曾食含碘食物的Graves病患者20例,在禁食含碘食物前后分两次进行摄131I试验与甲状腺99mTc显像,前者测定3、24 h摄131I率,后者计算摄锝指数(TI)及估算甲状腺质量(TW)。采用Wilcoxon 符号秩和检验对数据进行对比分析。结果 20例患者禁止含碘食物前后的摄131I率显著不同,所有患者禁食含碘食物后3和24 h摄131I率均显著增高。TI 2例未变、2例增高、16例降低;TM18例减小、2例增大。较未禁食含碘食物的首次检测,两者均有显著性变化。结论 含碘食物对甲状腺摄取Na99mTcO4的影响与Na131I显著不同,含碘食物100%减低甲状腺131I的摄取而90%锝摄取增高。

Abstract: Objective To investigate the changes in 99mTc and 131I uptake in patients with Grave’s disease after intake of iodine-containing food.Methods The 3-hour and 24-hour radioactive iodine uptake (RAIU) and 99mTc uptake ratio (TI) were measured and the thyroid weight (TW) was estimated in 20 patients with Graves’ disease both before and after restraint of iodine-containing diet.Results Significant difference was found in RAIU and TI in patients after restraint of iodine-rich diet (Z=3.920, P=0.000 for 3-hour RAIU and Z=3.920, P=0.000 for 24-hour RAIU; Z=2.199, P=0.028 for TI and Z=3.920, P=0.000 for TW estimated from 99mTc images). The tendency in such changes was significantly different (Z=4.066, P=0.000 for RAIU and TI; Z=4.243, P=0.000 for RAIU and TW). After restraint of iodine-rich food, RAIU of 3-hour and 24-hour increased in all the patients, and TI decreased in 16, remained the same level in 2 and increased in 2 patients; TW decreased in 18 and increased in 2 patients.Conclusion Iodine-containing food has different effects on thyroid 131I and 99mTc uptakes, which decreases 131I uptake in all the patients and increases 99mTc in 90% of them.

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