南方医科大学学报

南方医科大学学报 ›› 2004, Vol. 24 ›› Issue (11): 1287-1288.

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和田地区维吾尔族、汉族人群HBsAg携带率的流行病学调查分析

库热西江·托呼提1, 哈木拉提·吾甫尔2, 张利占1, 怕丽达1, 哈巴尔·肉孜1, 哈力克·依米提1, 程钦1, 董宇莉1, 古丽娜·玉山1   

  1. 1. 墨玉县人民医院, 新疆, 和田, 848100;
    2. 新疆维吾尔医研究所, 新疆, 乌鲁木齐, 830001;
    3. 浙江省金华市人民医院, 浙江, 金华, 321000
  • 出版日期:2004-11-20 发布日期:2004-11-20
  • 基金资助:
    收稿日期:2004-5-11。
    作者简介:库热西江·托呼提(1966- ),男,主管检验师,毕业于第一军医大学硕士研究生课程班,现为人事部新疆少数民族青年科技人才特殊培养对象,委培在新疆维吾尔医研究所分子生物学研究室从事血型遗传学和维吾尔医学基础研究,电话:0903-6515535,E-mail:kuraxht@21cn.com

Epidemiological survey of HBsAg carriers in the Uighur and Han populations in the Khotan Area of Xinjiang Autonomous Region

Kurexijiang Tuohuti1, Hamulati Wufuer2, ZHANG Li-zhan1, Palida1, Habaer Rouzi1, Halike Yimiti1, Cheng Qin1, Dong Yu-li1, Gulina Yushan1   

  1. 1. 墨玉县人民医院, 新疆, 和田, 848100;
    2. 新疆维吾尔医研究所, 新疆, 乌鲁木齐, 830001;
    3. 浙江省金华市人民医院, 浙江, 金华, 321000
  • Online:2004-11-20 Published:2004-11-20

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摘要： 目的 了解和田地区维吾尔族(维族)、汉族人群中乙型肝类(乙肝)病毒(HBV) 无症状表面抗原(HBsAg)携带情况。方法 随机抽取墨玉县2 597人(维族2 022人,汉族575人)的血液样本,以胶体金标记双抗体夹心法检测乙肝表面抗原(HBsAg)。结果 维族人口HBsAg携带率1.48%(30/2022),男性为1.078%(20/1370)、女性为1.59%(10/652),平均年龄35 岁,男女之间无年龄、性别差异;而汉族人口HBsAg携带率为6.09%(30/575)、男性为5.6%(21/372)、女性为4.4%(9/203),男性平均年龄为36.3岁、女性为27.6岁,不同年龄、性别之间存在显著差异,且男性高于女性。本地区维族与汉族人口之间HBsAg携带率存在非常显著性差异(P<0.01)。结论 和田地区维族人群中乙肝HBsAg携带率与低感染区一致,而汉族人群感染率与内陆地区中度流行区一致。本地区维吾尔族乙肝感染率偏低可能跟维吾尔族的民俗、饮食习惯及生存环境,HLA 基因频率分布差异等因素有关。作者认为,HLA-Bw41等抗原可能为抗乙肝病毒感染(非易感性)的基因(抗原)。

Abstract: Objective To survey nonsymptomatic HBsAg carriers in the Uighur and Han populations in Khotan Area of Xinjiang Autonomous region.Methods HBsAg was detected using colloidal gold-labeled double antibody sandwich method.Results These investigations included 2 597 subjects consisting of 2 022 Uighur and 575 Han subjects. The total HBsAg carrier rate in the Uighur population was 1.48% (30/2 022), specifically 1.078% in male and 1.59% in female subjects. No significant differences were observed in the age between male and female HBsAg carriers, who had an average age of 35 years. In the Han population, the total HBsAg carrier rate was 6.09%(30/575), and was 5.6% in male and 4.4% in female subjects. The average age of the male carriers was 36.3 years and 27.6 years in the female carriers, which showed significant difference in respect to HBsAg carrier rate. The HBsAg carrier rate showed significant difference between Uighur and Han populations in Khotan Area (P<0.01).Conclusion s The HBsAg carrier rate in Uighur population in Khotan Area is consistent with that in areas with low HBV infection, whereas the Han population exhibit features similar to those in areas with moderately HBV prevalence in the inland regions. The low HBsAg carrier rate in Uighurs might be attributed to the their customs in diet, eating habit, local living environment and the difference in HLA gene distribution. The authors suppose that such antigens as HLA-Bw41 might be protective against HBV infection.

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