安定或/和硫酸镁在预防骶管阻滞引起局麻药毒性反应中的应用

南方医科大学学报 ›› 2004, Vol. 24 ›› Issue (10): 1205-1206,1209.

安定或/和硫酸镁在预防骶管阻滞引起局麻药毒性反应中的应用

杨天明, 范新民, 范学良

解放军第303医院麻醉科, 广西, 南宁, 530021

出版日期:2004-10-20 发布日期:2004-10-20
基金资助:
收稿日期:2004-1-8。
作者简介:杨天明(1968- ),男,主治医师,在职研究生,电话:0771-2870142

Value of magnesium sulfate and/or valium in preventing local anesthetic toxicicity of sacral block

YANG Tian-ming, FAN Xin-ming, FAN Xue-liang

解放军第303医院麻醉科, 广西, 南宁, 530021

Online:2004-10-20 Published:2004-10-20

摘要/Abstract

摘要： 目的探讨安定或/和硫酸镁在预防骶管阻滞引起局麻药毒性反应中的作用。方法240例病人随机分为A、B、C、D组,每组60例,各组间平均年龄、体质量及性别在统计学上无明显差异。A组不用硫酸镁或安定,骶管阻滞前10min静脉注射安定(B组)、硫酸镁(C组)、硫酸镁+安定(D组),观察局麻药的毒性反应情况。结果 B、C组毒性症状明显减少,与A组比较有显著差异(P<0.05);D组与A组比较有非常显著差异(P<0.01)。结论静脉注射安定或硫酸镁均可明显降低骶管阻滞局麻药毒性反应,二者联合应用效果更佳。

Abstract: Objective To study the effects of magnesium sulfate and/or valium in preventing local anesthetic toxicicity induced by sacral block.Methods A total of 240 adult patients scheduled for sacral block were randomized equally into four groups matched for sex,age and body weight. Ten minutes before sacral block,the patients in group B received valium (0.1mg/kg),group C received magnesium sulfate (50mg/kg),group D received both valium (0.1mg/kg) and magnesium sulfate (50 mg/kg). The control (group A) received neither valium nor magnesium sulfate. Local anesthetic toxicity was observed and recorded in all the groups. Results Local anesthetic toxicity was significantly decreased in group B and group C compared with group A (P<0.05),and the toxicity was even more significantly decreased in group D(P<0.01vsgroup A).Conclusion Local anesthetic toxicity of sacral block can be significantly decreased by intravenous injection of valium or magnesium sulfate,and their combination produces stronger effects.

中图分类号:

杨天明, 范新民, 范学良. 安定或/和硫酸镁在预防骶管阻滞引起局麻药毒性反应中的应用[J]. 南方医科大学学报, 2004, 24(10): 1205-1206,1209.

YANG Tian-ming, FAN Xin-ming, FAN Xue-liang. Value of magnesium sulfate and/or valium in preventing local anesthetic toxicicity of sacral block[J]. Journal of Southern Medical University, 2004, 24(10): 1205-1206,1209.

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