99mTc-MIBI脑SPECT对脑胶质瘤的诊断价值

南方医科大学学报 ›› 2004, Vol. 24 ›› Issue (10): 1184-1185.

^99mTc-MIBI脑SPECT对脑胶质瘤的诊断价值

范义湘¹, 罗荣城¹, 李贵平², 黄凯²

1. 南方医科大学南方医院肿瘤科, 广东, 广州, 510515;
2. 南方医科大学南方医院核医学科, 广东, 广州, 510515

出版日期:2004-10-20 发布日期:2004-10-20
基金资助:
收稿日期:2004-3-22。
作者简介:范义湘(1970- ),男,主治医师,讲师,在读博士研究生,电话:020-61641651,E-mail:fanyixiang@163.com

Diagnostic value of ^99mTc-MIBI brain SPECT for brain glioma

FAN Yi-xiang¹, LUO Rong-cheng¹, LI Gui-ping², HUANG Kai²

1. 南方医科大学南方医院肿瘤科, 广东, 广州, 510515;
2. 南方医科大学南方医院核医学科, 广东, 广州, 510515

Online:2004-10-20 Published:2004-10-20

摘要/Abstract

摘要： 目的探讨^99mTc-MIBI脑显像对脑胶质瘤的诊断价值。方法对59例脑胶质瘤患者、9例正常人、6例脑脓肿患者进行^99mTc-MIBI脑SPECT显像。判断病灶有无异常摄取并根据感兴趣区(ROI)计算肿瘤/非肿瘤比值(T/NT),计算^99mTc-MIBI脑显像对脑胶质瘤诊断的灵敏度、特异性、准确率。T/NT比值在胶质瘤、脑脓肿及正常组之间的比较采用t检验。结果 59例脑胶质瘤患者中,51例显像为阳性,诊断灵敏度86.4%、特异性66.7%、准确率82.4%。15例非胶质瘤受检者有5例阳性。脑胶质瘤组T/NT比值为2.6±1.2,明显高于正常组的1.1±0.2(t=3.6199,P<0.001)和脑脓肿组的1.5±0.5(t=2.1327,P<0.05)。结论用^99mTc-MIBI脑SPECT诊断脑胶质瘤灵敏度高,可以有效地鉴别良恶性病变。

Abstract: Objective To evaluate the value of ^99mTc-MIBI brain single-photon emission computerized tomography (SPECT) in diagnosis of glioma.Methods Fifty-nine patients with glioma,6 with brain abscess and 9 healthy controls underwent ^99mTc-MIBI brain SPECT,and the diagnostic indices such as the sensitivity,specificity and accuracy were calculated. The tumor to non-tumor (T/NT) ratios were calculated according to the region of interest (ROI) and compared between the glioma group,healthy control group and brain abscess group by t test. Results Among the 59 cases of glioma,51 showed positive results in ^99mTc-MIBI SPECT,along with one of the healthy controls and 4 of brain abscess patients. The sensitivity,specificity and accuracy of the diagnosis were 86.4%,66.7% and 82.4%,respectively. The T/NT ratio of brain glioma group was 2.6±1.2,significantly higher than that of normal group (t=3.6199,P<0.001) and brain abscess group (t=2.1327,P<0.05).Conclusion ^99mTc-MIBI brain SPECT is sensitive for diagnosis of brain glioma,and can distinguish malignant from benign lesions effectively.

中图分类号:

范义湘¹, 罗荣城¹, 李贵平², 黄凯². ^99mTc-MIBI脑SPECT对脑胶质瘤的诊断价值[J]. 南方医科大学学报, 2004, 24(10): 1184-1185.

FAN Yi-xiang¹, LUO Rong-cheng¹, LI Gui-ping², HUANG Kai². Diagnostic value of ^99mTc-MIBI brain SPECT for brain glioma[J]. Journal of Southern Medical University, 2004, 24(10): 1184-1185.

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